Selective Electrochemical Benzylic C(sp3)-H Oxidations in Fluoroalcohols

被引：1
|
作者：
Shen, Haiwei [1 ,2 ]
Yang, Bo [1 ]
Lin, Jiusheng [1 ]
Zheng, Mingyue [1 ,2 ]
Jiang, Hualiang [1 ,2 ]
机构：
[1] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmacol Sci & Technol, Hangzhou, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai, Peoples R China
来源：
CHEMISTRYSELECT | 2023年 / 8卷 / 27期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
C(sp(3))-H oxidation; electrochemical; aryl aldehydes; fluorinated ethers; eco-friendly; C-H OXIDATION; N-HYDROXYPHTHALIMIDE; METAL-FREE; ALKYLARENES; ACTIVATION; METHYLARENES; KETONES; OXYGEN;
D O I：
10.1002/slct.202302073
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A site-selective electrochemical benzylic C(sp(3))-H oxidation reaction of aryl alkanes has been reported for synthesis of the desired products. This method significantly expands the scope and enhances the selectivity of aryl aldehydes and fluorinated ethers. Electricity is used as a sustainable oxidant and promote H-2 evolution. This protocol is eco-friendly and easy to handle as it uses a simple undivided cell in mild conditions without employing any catalyst and oxidant.
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页数：4
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