Metal-free C-3 selective C(sp2)-C(sp3) heteroarylation of anilines with imidazo[1,2-a]pyridine derivatives via cross-dehydrogenative coupling

被引：2
|
作者：
Wang, Kai [1 ,2 ]
Du, Xiaoxue [1 ,2 ]
Zhang, Pengfei [3 ]
Wei, Zhenjiang [4 ]
Cao, Xian-Ting [1 ,2 ]
机构：
[1] Jining Med Univ, Coll Med Engn, Jining 272067, Peoples R China
[2] Jining Med Univ, Key Lab Med Funct Nanomat, Jining 272067, Peoples R China
[3] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China
[4] Shandong Med Technician Coll, Dept Pharmaceut Engn, Tai An 271016, Peoples R China
来源：
RSC ADVANCES | 2023年 / 13卷 / 31期
关键词：
C-H; BOND FORMATION; N-HYDROXYPHTHALIMIDE; WATER; HETEROCYCLES; ACTIVATION; ALKYLATION; AMINATION; EVOLUTION; STRATEGY;
D O I：
10.1039/d3ra03852a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2-a]pyridines via cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing N,N-dimethylaniline as the methylenation source and furnishing the C(sp(2))-C(sp(3)) functionalized products in good to excellent yields. Mechanism studies indicate that a radical pathway is responsible for this transformation.
引用
收藏
页码：21685 / 21689
页数：5
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