Skin Pigmentation Types, Causes and Treatment-A Review

被引:83
作者
Thawabteh, Amin Mahmood [1 ,2 ]
Jibreen, Alaa [3 ]
Karaman, Donia [4 ]
Thawabteh, Ala [5 ]
Karaman, Rafik [4 ,6 ]
机构
[1] Birzeit Univ, Fac Pharm Nursing & Hlth Profess, Ramallah 00972, Palestine
[2] Birzeit Univ, Gen Serv Dept, Gen Safety Sect, Bir Zeit 71939, Palestine
[3] Beit Jala Pharmaceut Co Ltd, Res & Dev Dept, Beit Jala 97300, Palestine
[4] Al Quds Univ, Fac Pharm, Pharmaceut Sci Dept, Jerusalem 20002, Palestine
[5] Al Quds Univ, Fac Hlth Profess, Med Imaging Dept, Jerusalem 20002, Palestine
[6] Univ Basilicata, Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy
来源
MOLECULES | 2023年 / 28卷 / 12期
关键词
skin pigmentation; melanin; tyrosinase inhibitors; hypopigmentation; hyperpigmentation; vitiligo; skin lightening; depigmentation; TRANEXAMIC ACID; ISHIGE-FOLIACEA; RUXOLITINIB CREAM; TOPICAL TREATMENT; JOJOBA OIL; IN-VITRO; VITILIGO; EFFICACY; HYPERPIGMENTATION; COMBINATION;
D O I
10.3390/molecules28124839
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted by genetics, UV exposure, and some drugs. Patients' physical appearance, psychological health, and social functioning are all impacted by a sizable number of skin conditions that cause pigmentary abnormalities. Hyperpigmentation, where pigment appears to overflow, and hypopigmentation, where pigment is reduced, are the two major classifications of skin pigmentation. Albinism, melasma, vitiligo, Addison's disease, and post-inflammatory hyperpigmentation, which can be brought on by eczema, acne vulgaris, and drug interactions, are the most common skin pigmentation disorders in clinical practice. Anti-inflammatory medications, antioxidants, and medications that inhibit tyrosinase, which prevents the production of melanin, are all possible treatments for pigmentation problems. Skin pigmentation can be treated orally and topically with medications, herbal remedies, and cosmetic products, but a doctor should always be consulted before beginning any new medicine or treatment plan. This review article explores the numerous types of pigmentation problems, their causes, and treatments, as well as the 25 plants, 4 marine species, and 17 topical and oral medications now on the market that have been clinically tested to treat skin diseases.
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页数:28
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