Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus)

被引：9

作者：

Freire-Cobo, Carmen ^{[1
,2
,5
]}

Rothwell, Emily S. ^{[4
]}

Varghese, Merina ^{[1
,2
]}

Edwards, Melise ^{[4
]}

Janssen, William G. M. ^{[1
,2
]}

Lacreuse, Agnes ^{[4
]}

Hof, Patrick R. ^{[1
,2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY USA

[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY USA

[3] Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY USA

[4] Univ Massachusetts, Dept Psychol & Brain Sci, Amherst, MA USA

[5] Ichan Sch Med Mt Sinai, Nash Family Dept Neurosci, POB 1065, 1 Gustave L Levy Pl, New York, NY 10029 USA

来源：

NEUROBIOLOGY OF AGING | 2023年 / 123卷

关键词：

Aging; Nonhuman primates; Alzheimer's disease; Beta amyloid; Microglial phenotypes; Dendritic spines; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; LONG-TERM; QUANTITATIVE-ANALYSIS; STEREOLOGIC ANALYSIS; PYRAMIDAL NEURONS; DENDRITIC SPINES; MICROGLIA; BETA; AGE;

D O I：

10.1016/j.neurobiolaging.2022.12.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The investigation of neurobiological and neuropathological changes that affect synaptic integrity and function with aging is key to understanding why the aging brain is vulnerable to Alzheimer's disease. We investigated the cellular characteristics in the cerebral cortex of behaviorally characterized marmosets, based on their trajectories of cognitive learning as they transitioned to old age. We found increased astrogliosis, increased phagocytic activity of microglial cells and differences in resting and reactive mi-croglial cell phenotypes in cognitively impaired compared to nonimpaired marmosets. Differences in amyloid beta deposition were not related to cognitive trajectory. However, we found age-related changes in density and morphology of dendritic spines in pyramidal neurons of layer 3 in the dorsolateral pre-frontal cortex and the CA1 field of the hippocampus between cohorts. Overall, our data suggest that an accelerated aging process, accompanied by neurodegeneration, that takes place in cognitively impaired aged marmosets and affects the plasticity of dendritic spines in cortical areas involved in cognition and points to mechanisms of neuronal vulnerability to aging. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：49 / 62

页数：14

共 84 条

[1]

Abbott DH, 2003, COMPARATIVE MED, V53, P339

[2] 3D Reconstruction of Histological Sections: Application to Mammary Gland Tissue [J].

Arganda-Carreras, Ignacio ;

Fernandez-Gonzalez, Rodrigo ;

Munoz-Barrutia, Arrate ;

Ortiz-De-Solorzano, Carlos .

MICROSCOPY RESEARCH AND TECHNIQUE, 2010, 73 (11) :1019-1029

[3] Studies of aging nonhuman primates illuminate the etiology of early-stage Alzheimer's-like neuropathology: An evolutionary perspective [J].

Arnsten, Amy F. T. ;

Datta, Dibyadeep ;

Preuss, Todd M. .

AMERICAN JOURNAL OF PRIMATOLOGY, 2021, 83 (11)

[4] Neuronal Distribution Across the Cerebral Cortex of the Marmoset Monkey (Callithrix jacchus) [J].

Atapour, Nafiseh ;

Majka, Piotr ;

Wolkowicz, Ianina H. ;

Malamanova, Daria ;

Worthy, Katrina H. ;

Rosa, Marcello G. P. .

CEREBRAL CORTEX, 2019, 29 (09) :3836-3863

[5] Epigenetic regulation of brain region-specific microglia clearance activity [J].

Ayata, Pinar ;

Badimon, Ana ;

Strasburger, Hayley J. ;

Duff, Mary Kaye ;

Montgomery, Sarah E. ;

Loh, Yong-Hwee E. ;

Ebert, Anja ;

Pimenova, Anna A. ;

Ramirez, Brianna R. ;

Chan, Andrew T. ;

Sullivan, Josefa M. ;

Purushothaman, Immanuel ;

Scarpa, Joseph R. ;

Goate, Alison M. ;

Busslinger, Meinrad ;

Shen, Li ;

Losic, Bojan ;

Schaefer, Anne .

NATURE NEUROSCIENCE, 2018, 21 (08) :1049-+

[6]

Baxter MG, 2001, HIPPOCAMPUS, V11, P61, DOI 10.1002/1098-1063(2001)11:1<61::AID-HIPO1021>3.3.CO

[7]

2-Q

[8] Do thin spines learn to be mushroom spines that remember? [J].

Bourne, Jennifer ;

Harris, Kristen M. .

CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (03) :381-386

[9] Senescent synapses and hippocampal circuit dynamics [J].

Burke, Sara N. ;

Barnes, Carol A. .

TRENDS IN NEUROSCIENCES, 2010, 33 (03) :153-161

[10] Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease:: Stereologic analysis of prefrontal cortex area 9 [J].

Bussière, T ;

Giannakopoulos, P ;

Bouras, C ;

Perl, DP ;

Morrison, JH ;

Hof, PR .

JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 463 (03) :281-302

← 1 2 3 4 5 6 7 8 9 →