Association between polymorphisms of the GSDMB gene and allergic rhinitis risk in the Chinese population: a case-control study

被引：5

作者：

Shamsi, Bilal Haider ^{[1
]}

Chen, Haiyuan ^{[2
]}

Yang, Xiong ^{[3
]}

Liu, Mingxia ^{[4
]}

Liu, Yonglin ^{[1
]}

机构：

[1] Northwest Univ, Shenmu Hosp, Dept Sci & Educ, Affiliated Shenmu Hosp, 61 Hepan Rd,Yingbin Rd St, Shenmu City 719300, Shaanxi, Peoples R China

[2] Northwest Univ, Shenmu Hosp, Dept Informat, Affiliated Shenmu Hosp, Shenmu, Peoples R China

[3] Northwest Univ, Shenmu Hosp, Dept Nephrol, Affiliated Shenmu Hosp, Shenmu, Peoples R China

[4] Northwest Univ, Shenmu Hosp, Dept Prevent & Protect, Affiliated Shenmu Hosp, Shenmu, Peoples R China

来源：

JOURNAL OF ASTHMA | 2023年 / 60卷 / 09期

关键词：

Chinese population; allergic rhinitis; GSDMB; single nucleotide polymorphisms; ASTHMA; VARIANTS; 17Q21;

D O I：

10.1080/02770903.2023.2185893

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BackgroundAllergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. GSDMB is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in GSDMB and AR risk in the Chinese population.MethodsWe performed a case-control study including 1005 cases and 1004 controls. Rs2305479, rs4795400, and rs12450091 in GSDMB were geneotyped using Agena MassARRAY. The relationships between GSDMB SNPs and AR risk were assessed by logistic regression analysis in PLINK1.9.ResultsOur study showed that rs4795400 was a protective factor for AR in overall (TT vs. CC: OR = 0.66, p = 0.009; TT vs. CC/TC: OR = 0.67, p = 0.008; additive: OR = 0.87, p = 0.042 males, people with BMI <= 24, and living in wind-blown sand area. Rs2305479 was associated with a reduced AR risk in males (TT vs. CC: OR = 0.47, p = 0.014; TT vs. CC/TC: OR = 0.43, p = 0.004). However, rs12450091 was a risk factor for AR in people living in the loess hilly region (CC: OR = 4.75, p = 0.047). The levels of EO and EO_per in the case group were significantly higher than those in the control group (p < 0.05).ConclusionThis study indicated that GSDMB polymorphisms (rs4795400, rs2305479, and rs12450091) were associated with AR susceptibility. Further studies are required to confirm our findings and to clarify the functional relationship.

引用

页码：1751 / 1760

页数：10

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