Caffeic Acid Has Antiviral Activity against Ilheus Virus In Vitro

被引：16

作者：

Saivish, Marielena Vogel ^{[1
,2
]}

Pacca, Carolina Colombelli ^{[1
,3
,4
]}

da Costa, Vivaldo Gomes ^{[3
]}

de Lima Menezes, Gabriela ^{[5
,6
]}

da Silva, Roosevelt Alves ^{[6
]}

Nebo, Liliane ^{[6
]}

da Silva, Gislaine Celestino Dutra ^{[1
]}

de Aguiar Milhim, Bruno Henrique Goncalves ^{[1
]}

da Silva Teixeira, Igor ^{[1
]}

Henrique, Tiago ^{[7
]}

Mistrao, Natalia Franco Bueno ^{[1
]}

Hernandes, Victor Miranda ^{[1
]}

Zini, Nathalia ^{[1
]}

de Carvalho, Ana Carolina ^{[2
]}

Fontoura, Marina Alves ^{[2
]}

Rahal, Paula ^{[3
]}

Sacchetto, Livia ^{[1
]}

Marques, Rafael Elias ^{[2
]}

Nogueira, Mauricio Lacerda ^{[1
,2
,8
]}

机构：

[1] Fac Med Sao Jose do Rio Preto, Dept Doencas Dermatol Infecciosas & Parasitarias, Lab Pesquisas Virol, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil

[2] Ctr Nacl Pesquisa Energia & Mat CNPEM, Brazilian Biosci Natl Lab, BR-13083100 Campinas, SP, Brazil

[3] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Dept Biol, Lab Estudos Genom, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil

[4] Faceres Med Sch, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil

[5] Univ Fed Rio Grande do Norte, Dept Biofis & Farmacol, BR-59072970 Natal, RN, Brazil

[6] Univ Fed Jatai, Unidade Especial Ciencias Exatas, BR-75801615 Jatai, GO, Brazil

[7] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Lab Marcadores Mol & Bioinformat, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil

[8] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 02期

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

Ilheus virus; caffeic acid; antiviral activity; inhibition; in silico analysis; A549; CELLS; ZIKA; INFECTION; MULTIPLICATION; FLAVIVIRUSES; DERIVATIVES; INHIBITION; EXPRESSION; BURDEN; PLASMA;

D O I：

10.3390/v15020494

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ilheus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to Ilheus fever, an emerging febrile disease like dengue fever with the potential to evolve into a severe neurological disease characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed the antiviral properties of caffeic acid, an abundant component of plant-based food products that is also compatible with the socioeconomic limitations associated with this neglected infectious disease. The in vitro activity of caffeic acid on ILHV replication was investigated in Vero and A549 cell lines using plaque assays, quantitative RT-PCR, and immunofluorescence assays. We observed that 500 mu M caffeic acid was virucidal against ILHV. Molecular docking indicated that caffeic acid might interact with an allosteric binding site on the envelope protein.

引用

页数：20

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