Lactate, histone lactylation and cancer hallmarks

被引：69
|
作者：
Lv, Xinyu [1 ]
Lv, Yingying [2 ]
Dai, Xiaofeng [1 ,3 ]
机构：
[1] Jiangnan Univ, Wuxi Sch Med, Wuxi 214122, Peoples R China
[2] Shanghai Pudong New Area Peoples Hosp, Dept Clin Lab, Shanghai 201299, Peoples R China
[3] Xi An Jiao Tong Univ, Natl Local Joint Engn Res Ctr Precis Surg & Regene, Shaanxi Prov Ctr Regenerat Med & Surg Engn, Affiliated Hosp 1, Xian 710061, Peoples R China
来源：
EXPERT REVIEWS IN MOLECULAR MEDICINE | 2023年 / 25卷
基金：
中国国家自然科学基金;
关键词：
Cancer; epigenesis; hallmark; histone lactylation; lactate; therapeutic translation; DEHYDROGENASE; 5; EXPRESSION; LACTIC-ACID; TUMOR; CELLS; METABOLISM; RESISTANCE; GLYCOLYSIS; PH; INHIBITION; HYPOXIA;
D O I：
10.1017/erm.2022.42
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Histone lactylation: from tumor lactate metabolism to epigenetic regulation
    Yu, Xiaoning
    Yang, Jing
    Xu, Jin
    Pan, Haoqi
    Wang, Wei
    Yu, Xianjun
    Shi, Si
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2024, 20 (05): : 1833 - 1854
  • [2] Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
    Pan, Lianhong
    Feng, Fan
    Wu, Jiaqin
    Fan, Shibing
    Han, Juanjuan
    Wang, Shunxi
    Yang, Li
    Liu, Wanqian
    Wang, Chunli
    Xu, Kang
    PHARMACOLOGICAL RESEARCH, 2022, 181
  • [3] The crosstalking of lactate-Histone lactylation and tumor
    Rong, Yao
    Dong, Fengyuan
    Zhang, Guiqian
    Tang, Mingzheng
    Zhao, Xiashuang
    Zhang, Yan
    Tao, Pengxian
    Cai, Hui
    PROTEOMICS CLINICAL APPLICATIONS, 2023, 17 (05)
  • [4] Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review)
    He, Yufen
    Huang, Yaxi
    Peng, Peng
    Yan, Qi
    Ran, Lidan
    ONCOLOGY REPORTS, 2025, 53 (01)
  • [5] Endothelial Cell-Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis
    Wu, Jinhui
    Hu, Miao
    Jiang, Heng
    Ma, Jun
    Xie, Chong
    Zhang, Zheng
    Zhou, Xin
    Zhao, Jianquan
    Tao, Zhengbo
    Meng, Yichen
    Cai, Zhuyun
    Song, Tengfei
    Zhang, Chenglin
    Gao, Rui
    Cai, Chang
    Song, Hongyuan
    Gao, Yang
    Lin, Tao
    Wang, Ce
    Zhou, Xuhui
    ADVANCED SCIENCE, 2023, 10 (31)
  • [6] Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies
    Wang, Wenjuan
    Wang, Hong
    Wang, Qi
    Yu, Xiaojing
    Ouyang, Liangliang
    FRONTIERS IN IMMUNOLOGY, 2025, 15
  • [7] Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?
    Gong, Hang
    Xu, Hui-Mei
    Ma, Yao-Hui
    Zhang, De-Kui
    PHARMACOLOGICAL RESEARCH, 2023, 194
  • [8] Mechanisms regulating wound healing: Functional changes in biology mediated by lactate and histone lactylation
    Wu, Huiting
    Liang, Wei
    Han, Meng
    Zhen, Yonghuan
    Chen, Lixia
    Li, Hua
    An, Yang
    JOURNAL OF CELLULAR PHYSIOLOGY, 2023, 238 (10) : 2243 - 2252
  • [9] Lactate and lactylation in cancer
    Chen, Jie
    Huang, Ziyue
    Chen, Ya
    Tian, Hao
    Chai, Peiwei
    Shen, Yongning
    Yao, Yiran
    Xu, Shiqiong
    Ge, Shengfang
    Jia, Renbing
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2025, 10 (01)
  • [10] The lactate metabolism and protein lactylation in epilepsy
    Kuang, Xi
    Chen, Shuang
    Ye, Qingmei
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2025, 18
12345