Roles of Histone Acetyltransferases and Deacetylases in the Retinal Development and Diseases

被引：9
作者：
Wang, Jingjing [1 ,2 ]
Feng, Shuyu [1 ,2 ]
Zhang, Qian [1 ,2 ]
Qin, Huan [1 ,2 ]
Xu, Chunxiu [1 ,2 ]
Fu, Xuefei [1 ,2 ]
Yan, Lin [1 ,2 ]
Zhao, Yaqin [1 ,2 ]
Yao, Kai [1 ,2 ,3 ]
机构：
[1] Wuhan Univ Sci & Technol, Inst Visual Neurosci & Stem Cell Engn, Wuhan 430065, Peoples R China
[2] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China
[3] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 04期
基金：
中国国家自然科学基金;
关键词：
HATs; HDACs; HDAC inhibitor; Retinal development; Retinal aging; Retinal diseases; DIABETIC-RETINOPATHY; VALPROIC ACID; CELL-DEATH; METABOLIC MEMORY; PHOTORECEPTOR DIFFERENTIATION; TRANSCRIPTIONAL ACTIVITY; EPIGENETIC MODIFICATIONS; INFLAMMATORY RESPONSE; NUCLEAR ATROPHY; GENE-EXPRESSION;
D O I：
10.1007/s12035-023-03213-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The critical role of epigenetic modification of histones in maintaining the normal function of the nervous system has attracted increasing attention. Among these modifications, the level of histone acetylation, modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is essential in regulating gene expression. In recent years, the research progress on the function of HDACs in retinal development and disease has advanced remarkably, while that regarding HATs remains to be investigated. Here, we overview the roles of HATs and HDACs in regulating the development of diverse retinal cells, including retinal progenitor cells, photoreceptor cells, bipolar cells, ganglion cells, and Muller glial cells. The effects of HATs and HDACs on the progression of various retinal diseases are also discussed with the highlight of the proof-of-concept research regarding the application of available HDAC inhibitors in treating retinal diseases.
引用
收藏
页码：2330 / 2354
页数：25
相关论文
共 195 条
  • [1] Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy
    Abouhish, Hossameldin
    Thounaojam, Menaka C.
    Jadeja, Ravirajsinh N.
    Gutsaeva, Diana R.
    Powell, Folami L.
    Khriza, Mohamed
    Martin, Pamela M.
    Bartoli, Manuela
    [J]. ANTIOXIDANTS, 2020, 9 (07) : 1 - 19
  • [2] Redox Signaling via Lipid Peroxidation Regulates Retinal Progenitor Cell Differentiation
    Albadri, Shahad
    Naso, Federica
    Thauvin, Marion
    Gauron, Carole
    Parolin, Carola
    Duroure, Karine
    Vougny, Juliette
    Fiori, Jessica
    Boga, Carla
    Vriz, Sophie
    Calonghi, Natalia
    Del Bene, Filippo
    [J]. DEVELOPMENTAL CELL, 2019, 50 (01) : 73 - +
  • [3] The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis
    Aldiri, Issam
    Xu, Beisi
    Wang, Lu
    Chen, Xiang
    Hiler, Daniel
    Griffiths, Lyra
    Valentine, Marc
    Shirinifard, Abbas
    Thiagarajan, Suresh
    Sablauer, Andras
    Barabas, Marie-Elizabeth
    Zhang, Jiakun
    Johnson, Dianna
    Frase, Sharon
    Zhou, Xin
    Easton, John
    Zhang, Jinghui
    Mardis, Elaine R.
    Wilson, Richard K.
    Downing, James R.
    Dyer, Michael A.
    [J]. NEURON, 2017, 94 (03) : 550 - +
  • [4] Acetylation: A lysine modification with neuroprotective effects in ischemic retinal degeneration
    Alsarraf, Oday
    Fan, Jie
    Dahrouj, Mohammad
    Chou, C. James
    Menick, Donald R.
    Crosson, Craig E.
    [J]. EXPERIMENTAL EYE RESEARCH, 2014, 127 : 124 - 131
  • [5] Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain
    Anderson, Kyle W.
    Chen, Junjun
    Wang, Meiyao
    Mast, Natalia
    Pikuleva, Irina A.
    Turko, Illarion V.
    [J]. PLOS ONE, 2015, 10 (05):
  • [6] Light-dark condition regulates sirtuin mRNA levels in the retina
    Ban, Norimitsu
    Ozawa, Yoko
    Inaba, Takaaki
    Miyake, Seiji
    Watanabe, Mitsuhiro
    Shinmura, Ken
    Tsubota, Kazuo
    [J]. EXPERIMENTAL GERONTOLOGY, 2013, 48 (11) : 1212 - 1217
  • [7] Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription
    Barnes, Claire E.
    English, David M.
    Cowley, Shaun M.
    [J]. DNA PACKAGING: NUCLEOSOME AND CHROMATIN, 2019, 63 (01): : 97 - 107
  • [8] Ubiquitous Chromatin Modifiers in Congenital Retinal Diseases: Implications for Disease Modeling and Regenerative Medicine
    Basinski, Brian W.
    Balikov, Daniel A.
    Aksu, Michael
    Li, Qiang
    Rao, Rajesh C.
    [J]. TRENDS IN MOLECULAR MEDICINE, 2021, 27 (04) : 365 - 378
  • [9] Cell fate determination in the vertebrate retina
    Bassett, Erin A.
    Wallace, Valerie A.
    [J]. TRENDS IN NEUROSCIENCES, 2012, 35 (09) : 565 - 573
  • [10] HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
    Bermudez, Jaclyn Y.
    Webber, Hannah C.
    Patel, Gaurang C.
    Liu, Xiangyang
    Cheng, Yi-Qiang
    Clark, Abbot E.
    Mao, Weiming
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (08) : 3698 - 3707
12345678910