Roles of Histone Acetyltransferases and Deacetylases in the Retinal Development and Diseases

被引：15
作者：
Wang, Jingjing [1 ,2 ]
Feng, Shuyu [1 ,2 ]
Zhang, Qian [1 ,2 ]
Qin, Huan [1 ,2 ]
Xu, Chunxiu [1 ,2 ]
Fu, Xuefei [1 ,2 ]
Yan, Lin [1 ,2 ]
Zhao, Yaqin [1 ,2 ]
Yao, Kai [1 ,2 ,3 ]
机构：
[1] Wuhan Univ Sci & Technol, Inst Visual Neurosci & Stem Cell Engn, Wuhan 430065, Peoples R China
[2] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China
[3] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 04期
基金：
中国国家自然科学基金;
关键词：
HATs; HDACs; HDAC inhibitor; Retinal development; Retinal aging; Retinal diseases; DIABETIC-RETINOPATHY; VALPROIC ACID; CELL-DEATH; METABOLIC MEMORY; PHOTORECEPTOR DIFFERENTIATION; TRANSCRIPTIONAL ACTIVITY; EPIGENETIC MODIFICATIONS; INFLAMMATORY RESPONSE; NUCLEAR ATROPHY; GENE-EXPRESSION;
D O I：
10.1007/s12035-023-03213-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The critical role of epigenetic modification of histones in maintaining the normal function of the nervous system has attracted increasing attention. Among these modifications, the level of histone acetylation, modulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is essential in regulating gene expression. In recent years, the research progress on the function of HDACs in retinal development and disease has advanced remarkably, while that regarding HATs remains to be investigated. Here, we overview the roles of HATs and HDACs in regulating the development of diverse retinal cells, including retinal progenitor cells, photoreceptor cells, bipolar cells, ganglion cells, and Muller glial cells. The effects of HATs and HDACs on the progression of various retinal diseases are also discussed with the highlight of the proof-of-concept research regarding the application of available HDAC inhibitors in treating retinal diseases.
引用
收藏
页码：2330 / 2354
页数：25
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