A one-pot synthesis 3-alkoxycarbonyl-3,4-dihydro-2H-pyran-2-ones from vinylidene melderum's acids, dialkyl acetylenedicarboxylates, and simple alcohols

被引：15

作者：

Khandan, Samira ^{[1
]}

Yavari, Issa ^{[2
]}

Azizian, Javad ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Sci & Res Branch, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran

来源：

MOLECULAR DIVERSITY | 2023年 / 27卷 / 01期

关键词：

3-Alkoxycarbonyl-3,4-dihydro-2H-pyran-2-ones; Melderum's acid; Acetylenic ester; Hetero-Diels-Alder reaction; Antioxidant property; Antimicrobial activity; ANTITUMOR-ACTIVITY; PART; 2; INHIBITOR;

D O I：

10.1007/s11030-022-10407-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A one-pot synthesis of 3-alkoxycarbonyl-3,4-dihydro-2H-pyran-2-ones from intermolecular hetero-Diels-Alder reaction between vinylidene Melderum's acids and dialkyl acetylenedicarboxylates, in the presence of simple alcohols at room temperature, is described. The advantages of this procedure are good yields, short reaction time, and easy workup. Antioxidant properties of four derivatives of these 3,4-dihydro-2H-pyran-2-ones, together with their antimicrobial activities, are investigated. [GRAPHICS]

引用

页码：125 / 133

页数：9

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