Emerging Progress of RNA-Based Antitumor Therapeutics

被引：10
作者：
Fu, Jiayan [1 ,2 ,3 ]
Dong, Haiyang [1 ,2 ,3 ]
Wu, Jian [4 ]
Jin, Yongfeng [1 ,2 ,3 ,5 ,6 ]
机构：
[1] Zhejiang Univ, Natl Key Lab Adv Drug Delivery & Release Syst, Hangzhou 310058, Peoples R China
[2] Zhejiang Univ, Coll Life Sci, Innovat Ctr Cell Signaling Network, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Peoples R China
[3] Zhejiang Univ, Canc Ctr, Hangzhou 310058, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China
[5] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurosurg, Hangzhou 310006, Peoples R China
[6] Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 10期
基金：
中国国家自然科学基金;
关键词：
RNA; therapeutics; modification; delivery; tumor-treatment; CHIMERIC ANTIGEN RECEPTOR; EUKARYOTIC MESSENGER-RNA; PEPTIDE NUCLEIC-ACIDS; AUG INITIATOR CODON; DOUBLE-STRANDED-RNA; LIPID NANOPARTICLES; ANTISENSE OLIGONUCLEOTIDES; GENE-EXPRESSION; IN-VITRO; TARGETED DELIVERY;
D O I：
10.7150/ijbs.83732
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA-based therapeutics (e.g., mRNAs, siRNAs, microRNAs, ASOs, and saRNAs) have considerable potential for tumor treatment. The development and optimization of RNA modifications and delivery systems enable the stable and efficient delivery of RNA cargos in vivo to elicit an antitumor response. Targeted RNA-based therapeutics with multiple specificities and high efficacies are now available. In this review, we discuss progress in RNA-based antitumor therapeutics, including mRNAs, siRNAs, miRNAs, ASOs, saRNAs, RNA aptamers, and CRISPR-based gene editing. We focus on the immunogenicity, stability, translation efficiency, and delivery of RNA drugs, and summarize their optimization and the development of delivery systems. In addition, we describe the mechanisms by which RNA-based therapeutics induce antitumor responses. Furthermore, we review the merits and limitations of RNA cargos and their therapeutic potential for cancers.
引用
收藏
页码：3159 / 3183
页数：25
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