Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension

被引：23
|
作者：
Ma, Binghao [1 ,2 ,3 ]
Cao, Yuanyuan [1 ,2 ,3 ]
Qin, Jia [1 ,2 ,3 ]
Chen, Zhuo [1 ,2 ,3 ]
Hu, Gaoyun [1 ,2 ,3 ]
Li, Qianbin [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Sch Pharmaceut Sci, Dept Med Chem, Changsha 410013, Hunan, Peoples R China
[2] Hunan Key Lab Small Mol Diag & Treatment Chron Dis, Changsha 410013, Hunan, Peoples R China
[3] Hunan Key Lab Organ Fibrosis, Changsha 410013, Hunan, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 05期
基金：
中国国家自然科学基金;
关键词：
pulmonary arterial hypertension; pulmonary smooth muscle cells; early stage; phenotypic switching; signaling pathways; small molecular regulators; INDUCED PROLIFERATION; DNA METHYLATION; GENE-EXPRESSION; GROWTH; MECHANISMS; DIFFERENTIATION; MODULATION; MIGRATION; RECEPTOR; ACTIVATION;
D O I：
10.1016/j.drudis.2023.103559
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pulmonary arterial hypertension (PAH) is a currently incurable pulmonary vascular disease. Since current research on PAH is mainly aimed at the middle and late stages of disease progression, no satisfactory results have been achieved. This has led researchers to focus on the early stages of PAH. This review highlights for the first time a key event in the early stages of PAH progression, namely, the occurrence of pulmonary arterial smooth the related reports of phenotypic switching provides new perspectives and directions for the early pathological progression and treatment strategies for PAH.
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页数：13
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