Evaluating Nonoperative Treatment for Low Back Pain in the Presence of Modic Changes: A Systematic Review

OBJECTIVE: The objective of this study was to summa-rize and assess the current literature evaluating nonoper-ative treatments for patients with Modic changes (MCs) and low back pain (LBP). METHODS: A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed database was searched from its inception until May 1, 2022 for studies evaluating MC and clinical out-comes. Key findings, treatment details, and patient infor-mation were extracted from included studies. Study quality was assessed using the NewcastleeOttawa Scale.RESULTS: Eighteen studies were included in this review, encompassing a total of 2452 patients, 1713 of whom dis-played baseline MC. Seventy-eight percent of studies were high quality. Of included studies, 2 evaluated antibiotics, 5 evaluated steroid injections, 6 evaluated conservative therapies, and 5 evaluated other treatment modalities. Antibiotics and bisphosphonates improved treatment in patients with MC. Patients with MC without disc herniation benefited from conservative therapy, while those with Type I Modic changes and disc herniation experienced poorer improvement. Significant variability exists in reported outcomes following steroid injections.CONCLUSIONS: Nonoperative therapy may provide pa-tients with MC with significant benefits. Patients may benefit from therapies not traditionally utilized for LBP such as antibiotics or bisphosphonates, but conservative therapy is not recommended for patients with concomitant MC and disc herniation. The large variation in follow-up times and outcome measures contributes to significant heterogeneity in studies and inability to predict long-term patient outcomes. More long-term studies are needed to assess nonoperative treatments for LBP in patients with MC.