A single-step plasma method for rapid production of 2D, ferromagnetic, surface vacancy-engineered MoO3-x nanomaterials, for photothermal ablation of cancer

被引:4
作者
Rahman, Mizanur [1 ,2 ]
Pemmaraju, Deepak B. [3 ]
Murty, Upadhyayula Suryanarayana [3 ]
Phukan, Sarat [4 ]
Deshpande, Uday P. [5 ]
Sathe, Vasant [5 ]
Kakati, Mayur [1 ,2 ]
机构
[1] Inst Plasma Res, Ctr Plasma Phys, CIMPLE PSI Lab, Sonapur 782402, Assam, India
[2] Gauhati Univ, Dept Phys, Gauhati 781014, Assam, India
[3] Natl Inst Pharmaceut Educ & Res NIPER Guwahati, Dept Pharmacol & Toxicol, Changsari 781101, Assam, India
[4] Gauhati Univ, Dept Geol, Gauhati 781014, Assam, India
[5] UGC DAE Consortium Sci Res, Indore 452027, Madhya Pradesh, India
关键词
plasma-synthesis; vacancy-engineering; photonic nanomaterials; ferromagnetism; photothermal therapy; MOLYBDENUM OXIDE; OXYGEN VACANCIES; HYDROGENATION; NANOSHEETS; RESONANCE; OXIDATION; EFFICIENT; DIOXIDE;
D O I
10.1088/1361-6528/acb827
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
A rapid, clean plasma-chemical technique is demonstrated here, for cost-effective, synthesis of surface vacancy engineered, 2D, molybdenum-oxide nanomaterials, during a one-step, integrated synthesis-hydrogenation process for biomedical applications. A laminar plasma beam populated with O and H radicals impinges on a molybdenum target, out of which molybdenum-oxide nanomaterials are very rapidly generated with controlled surface O vacancies. 2D, dark-blue coloured, nano-flake/ribbon like MoO3-x is produced maximum up to 194 g h(-1), the core of which still remains as stoichiometric molybdenum-oxide. These nanomaterials can get heated-up by absorbing energy from a near-infrared (NIR) laser, which enable them as photothermal therapy (PTT) candidate material for the invasive precision therapy of cancer. The surface defects endows the products with robust ferromagnetism at room temperature conditions (maximum saturation-magnetization: 6.58 emu g(-1)), which is order of magnitude stronger than most other vacancy engineered nanomaterials. These nanometric metal-oxides are observed to be perfectly compatible in animal physiological environment and easily dispersed in an aqueous solution even without any pre-treatment. The MoO3-x nanomaterials are stable against further oxidation even under prolonged atmospheric exposure. In vitro experiments confirm that they have ideal efficacy for photothermal ablation of human and murine melanoma cancer at relatively lower dose. During in vivo PTT treatments, they may be manipulated with a simple external magnetic field for targeted delivery at the malignant tumours. It is demonstrated that commensurate to the neutralization of the malignant cells, the nanomaterials themselves get self-degraded, which should get easily excreted out of the body.
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页数:12
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