HLA and red blood cell antigen genotyping in SARS-CoV-2 convalescent plasma donors

被引：0

作者：

Lemieux, William ^{[1
,2
]}

Perreault, Josee ^{[1
,2
]}

Leiva-Torres, Gabriel Andre ^{[3
,4
]}

Baillargeon, Nadia ^{[3
,4
]}

Yanez, Jessica Constanzo ^{[3
,4
]}

Chevrier, Marie-Claire ^{[3
,4
]}

Richard, Lucie ^{[3
,4
]}

Lewin, Antoine ^{[1
,2
]}

Trepanier, Patrick ^{[1
,2
]}

机构：

[1] Hema Quebec, Med Affairs & Innovat, Quebec City, PQ G1V 5G3, Canada

[2] Hema Quebec, Med Affairs & Innovat, Montreal, PQ G1V 5G3, Canada

[3] Hema Quebec, Transfus Med, Quebec City, PQ H4R 2W7, Canada

[4] Hema Quebec, Transfus Med, Montreal, PQ H4R 2W7, Canada

来源：

FUTURE VIROLOGY | 2023年 / 18卷 / 02期

关键词：

COVID-19; human leukocyte antigens; red blood cell antigens; SARS-CoV-2; susceptibility; INFECTION; SAMPLES;

D O I：

10.2217/fvl-2022-0058

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: More data is required regarding the association between HLA allele and red blood cell (RBC) antigen expression in regard to SARS-CoV-2 infection and COVID-19 susceptibility. Methods: ABO, RhD, 37 other RBC antigens and HLA-A, B, C, DRB1, DQB1 and DPB1 were determined using high throughput platforms in 90 Caucasian convalescent plasma donors. Results: The AB group was significantly increased (1.5x, p = 0.018) and some HLA alleles were found to be significantly overrepresented (HLA-B*44:02, C*05:01, DPB1*04:01, DRB1*04:01 and DRB1*07:01) or underrepresented (A*01:01, B51:01 and DPB1*04:02) in convalescent individuals compared with the local bone marrow registry population. Conclusion: Our study of infection-susceptible but non-hospitalized Caucasian COVID-19 patients contributes to the global understanding of host genetic factors associated with SARS-CoV-2 infection and severity.

引用

页码：107 / 117

页数：11

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