HLA and red blood cell antigen genotyping in SARS-CoV-2 convalescent plasma donors

被引：0
|
作者：
Lemieux, William [1 ,2 ]
Perreault, Josee [1 ,2 ]
Leiva-Torres, Gabriel Andre [3 ,4 ]
Baillargeon, Nadia [3 ,4 ]
Yanez, Jessica Constanzo [3 ,4 ]
Chevrier, Marie-Claire [3 ,4 ]
Richard, Lucie [3 ,4 ]
Lewin, Antoine [1 ,2 ]
Trepanier, Patrick [1 ,2 ]
机构：
[1] Hema Quebec, Med Affairs & Innovat, Quebec City, PQ G1V 5G3, Canada
[2] Hema Quebec, Med Affairs & Innovat, Montreal, PQ G1V 5G3, Canada
[3] Hema Quebec, Transfus Med, Quebec City, PQ H4R 2W7, Canada
[4] Hema Quebec, Transfus Med, Montreal, PQ H4R 2W7, Canada
来源：
FUTURE VIROLOGY | 2023年 / 18卷 / 02期
关键词：
COVID-19; human leukocyte antigens; red blood cell antigens; SARS-CoV-2; susceptibility; INFECTION; SAMPLES;
D O I：
10.2217/fvl-2022-0058
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: More data is required regarding the association between HLA allele and red blood cell (RBC) antigen expression in regard to SARS-CoV-2 infection and COVID-19 susceptibility. Methods: ABO, RhD, 37 other RBC antigens and HLA-A, B, C, DRB1, DQB1 and DPB1 were determined using high throughput platforms in 90 Caucasian convalescent plasma donors. Results: The AB group was significantly increased (1.5x, p = 0.018) and some HLA alleles were found to be significantly overrepresented (HLA-B*44:02, C*05:01, DPB1*04:01, DRB1*04:01 and DRB1*07:01) or underrepresented (A*01:01, B51:01 and DPB1*04:02) in convalescent individuals compared with the local bone marrow registry population. Conclusion: Our study of infection-susceptible but non-hospitalized Caucasian COVID-19 patients contributes to the global understanding of host genetic factors associated with SARS-CoV-2 infection and severity.
引用
收藏
页码：107 / 117
页数：11
相关论文
共 50 条
  • [21] SARS-CoV-2 seroprevalence in Nova Scotia blood donors
    O'Brien, Sheila F.
    Deeks, Shelley L.
    Hatchette, Todd
    Pambrun, Chantale
    Drews, Steven J.
    JOURNAL OF THE ASSOCIATION OF MEDICAL MICROBIOLOGY AND INFECTIOUS DISEASE CANADA (JAMMI), 2024, 9 (01): : 32 - 45
  • [22] Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray
    de Assis, Rafael R.
    Jain, Aarti
    Nakajima, Rie
    Jasinskas, Algis
    Felgner, Jiin
    Obiero, Joshua M.
    Norris, Philip J.
    Stone, Mars
    Simmons, Graham
    Bagri, Anil
    Irsch, Johannes
    Schreiber, Martin
    Buser, Andreas
    Holbro, Andreas
    Battegay, Manuel
    Hosimer, Philip
    Noesen, Charles
    Adenaiye, Oluwasanmi
    Tai, Sheldon
    Hong, Filbert
    Milton, Donald K.
    Davies, D. Huw
    Contestable, Paul
    Corash, Laurence M.
    Busch, Michael P.
    Felgner, Philip L.
    Khan, Saahir
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [23] SARS-CoV-2 antibody levels and long COVID occurrence in blood donors
    Avelino-Silva, Vivian I.
    Bruhn, Roberta
    Zurita, Karla G.
    Deng, Xutao
    Yu, Elaine A.
    Grebe, Eduard
    Stone, Mars
    Lanteri, Marion C.
    Spencer, Bryan R.
    Busch, Michael P.
    Custer, Brian
    TRANSFUSION, 2024, 64 (09) : 1719 - 1731
  • [24] SARS-COV-2 Infection in Children and Red Blood Cell Distribution Width
    Kuekou, Hyppolite Tchidjou
    Palandri, Lucia
    Pouplin, Suzanne
    Te, Valerie LiThiao
    Righi, Elena
    Castelain, Sandrine
    Ricard, Jannick
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (09)
  • [25] Potential use of convalescent plasma for SARS-CoV-2 prophylaxis and treatment in immunocompromised and vulnerable populations
    Focosi, Daniele
    Franchini, Massimo
    EXPERT REVIEW OF VACCINES, 2022, 21 (07) : 877 - 884
  • [26] Convalescent plasma therapy against the emerging SARS-CoV-2 variants: Delineation of the potentialities and risks
    Dhawan, Manish
    Priyanka
    Parmar, Manisha
    Angural, Steffy
    Choudhary, Om Prakash
    INTERNATIONAL JOURNAL OF SURGERY, 2022, 97
  • [27] Red blood cell exchange for SARS-CoV-2: A Gemini of therapeutic opportunities
    Hacking, Sean M.
    MEDICAL HYPOTHESES, 2020, 144
  • [28] SARS-CoV-2 convalescent plasma therapy in pediatric patient after hematopoietic stem cell transplantation
    Balashov, Dmitry
    Trakhtman, Pavel
    Livshits, Anna
    Kovalenko, Irina
    Tereshenko, Galina
    Solopova, Galina
    Petraikina, Elena
    Maschan, Alexei
    Novichkova, Galina
    TRANSFUSION AND APHERESIS SCIENCE, 2021, 60 (01)
  • [29] Peripheral Blood Immune Profiling of Convalescent Plasma Donors Reveals Alterations in Specific Immune Subpopulations Even at 2 Months Post SARS-CoV-2 Infection
    Orologas-Stavrou, Nikolaos
    Politou, Marianna
    Rousakis, Pantelis
    Kostopoulos, Ioannis V.
    Ntanasis-Stathopoulos, Ioannis
    Jahaj, Edison
    Tsiligkeridou, Eleni
    Gavriatopoulou, Maria
    Kastritis, Efstathios
    Kotanidou, Anastasia
    Dimopoulos, Meletios-Athanasios
    Tsitsilonis, Ourania E.
    Terpos, Evangelos
    VIRUSES-BASEL, 2021, 13 (01):
  • [30] Pathology of Red Blood Cells in Patients with SARS-CoV-2
    Hakobyan, Sona
    Hakobyan, Lina
    Abroyan, Liana
    Avetisyan, Aida
    Avagyan, Hranush
    Bayramyan, Nane
    Niazyan, Lyudmila
    Davidyants, Mher
    Sargsyan, Knarik
    Ghalechyan, Tehmine
    Semerjyan, Anna
    Karalova, Elena
    Karalyan, Zaven
    BIOMEDICINES, 2025, 13 (01)
12345