HLA and red blood cell antigen genotyping in SARS-CoV-2 convalescent plasma donors

被引：0
|
作者：
Lemieux, William [1 ,2 ]
Perreault, Josee [1 ,2 ]
Leiva-Torres, Gabriel Andre [3 ,4 ]
Baillargeon, Nadia [3 ,4 ]
Yanez, Jessica Constanzo [3 ,4 ]
Chevrier, Marie-Claire [3 ,4 ]
Richard, Lucie [3 ,4 ]
Lewin, Antoine [1 ,2 ]
Trepanier, Patrick [1 ,2 ]
机构：
[1] Hema Quebec, Med Affairs & Innovat, Quebec City, PQ G1V 5G3, Canada
[2] Hema Quebec, Med Affairs & Innovat, Montreal, PQ G1V 5G3, Canada
[3] Hema Quebec, Transfus Med, Quebec City, PQ H4R 2W7, Canada
[4] Hema Quebec, Transfus Med, Montreal, PQ H4R 2W7, Canada
来源：
FUTURE VIROLOGY | 2023年 / 18卷 / 02期
关键词：
COVID-19; human leukocyte antigens; red blood cell antigens; SARS-CoV-2; susceptibility; INFECTION; SAMPLES;
D O I：
10.2217/fvl-2022-0058
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: More data is required regarding the association between HLA allele and red blood cell (RBC) antigen expression in regard to SARS-CoV-2 infection and COVID-19 susceptibility. Methods: ABO, RhD, 37 other RBC antigens and HLA-A, B, C, DRB1, DQB1 and DPB1 were determined using high throughput platforms in 90 Caucasian convalescent plasma donors. Results: The AB group was significantly increased (1.5x, p = 0.018) and some HLA alleles were found to be significantly overrepresented (HLA-B*44:02, C*05:01, DPB1*04:01, DRB1*04:01 and DRB1*07:01) or underrepresented (A*01:01, B51:01 and DPB1*04:02) in convalescent individuals compared with the local bone marrow registry population. Conclusion: Our study of infection-susceptible but non-hospitalized Caucasian COVID-19 patients contributes to the global understanding of host genetic factors associated with SARS-CoV-2 infection and severity.
引用
收藏
页码：107 / 117
页数：11
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