Precision nephrotoxicity testing using 3D in vitro models

被引：5

作者：

Yu, Pengfei ^{[1
,2
]}

Zhu, Hainan ^{[1
]}

Bosholm, Carol Christine ^{[1
]}

Beiner, Daniella ^{[1
]}

Duan, Zhongping ^{[2
]}

Shetty, Avinash K. ^{[3
]}

Mou, Steve S. ^{[4
]}

Kramer, Philip Adam ^{[5
]}

Barroso, Luis F. ^{[6
]}

Liu, Hongbing ^{[7
,8
]}

Cheng, Kun ^{[9
]}

Ihnat, Michael ^{[10
]}

Gorris, Matthew A. ^{[11
]}

Aloi, Joseph A. ^{[11
]}

Woldemichael, Jobira A. ^{[12
]}

Bleyer, Anthony ^{[12
]}

Zhang, Yuanyuan ^{[1
]}

机构：

[1] Wake Forest Univ Hlth Sci, Wake Forest Inst Regenerat Med, Winston Salem, NC 27101 USA

[2] Capital Med Univ, Beijing You An Hosp, Dept Liver Dis 4, Beijing, Peoples R China

[3] Wake Forest Univ, Sch Med, Dept Pediat, Winston Salem, NC USA

[4] Wake Forest Univ, Sch Med, Dept Anesthesiol & Pediat, Winston Salem, NC USA

[5] Wake Forest Univ, Sch Med, Dept Internal Med, Sect Gerontol & Geriatr, Winston Salem, NC 27109 USA

[6] Wake Forest Univ Hlth Sci, Internal Med Infect Dis, Winston Salem, NC USA

[7] Tulane Univ, Sch Med, Dept Pediat, Tulane Ave, New Orleans, LA USA

[8] Tulane Univ, Sch Med, Tulane Hypertens & Renal Ctr Excellence, Tulane Ave, New Orleans, LA USA

[9] Univ Missouri, Sch Pharm, Div Pharmacol & Pharmaceut Sci, 2464 Charlotte St, Kansas City, MO 64108 USA

[10] Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK USA

[11] Wake Forest Baptist Med Ctr, Div Endocrinol & Metab, Winston Salem, NC USA

[12] Wake Forest Univ Hlth Sci, Div Nephrol, Winston Salem, NC USA

来源：

CELL AND BIOSCIENCE | 2023年 / 13卷 / 01期

关键词：

Precision medicine; Nephrotoxicity; Drug toxicity testing; 3D culture model; Human primary renal cells; PLURIPOTENT STEM-CELLS; HIV-INFECTED PATIENTS; ON-A-CHIP; KIDNEY ORGANOIDS; PROXIMAL TUBULE; EXPRESSION; CULTURE; BIOMARKERS; TENOFOVIR; DISEASE;

D O I：

10.1186/s13578-023-01187-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.

引用

页数：16

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