GBCdb: RNA expression landscapes and ncRNA-mRNA interactions in gallbladder carcinoma

被引:5
|
作者
Guo, Li [1 ]
Xiang, Yangyang [1 ]
Dou, Yuyang [1 ]
Yin, Zibo [1 ]
Xu, Xinru [2 ]
Tang, Lihua [1 ]
Yu, Jiafeng [3 ]
Wang, Jun [1 ]
Liang, Tingming [2 ]
机构
[1] Nanjing Univ Posts & Telecommun, Sch Geog & Biol Informat, Dept Bioinformat, Smart Hlth Big Data Anal & Locat Serv Engn Lab Jia, Nanjing 210023, Peoples R China
[2] Nanjing Normal Univ, Sch Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Peoples R China
[3] Dezhou Univ, Inst Biophys, Shandong Prov Key Lab Biophys, Dezhou 253023, Peoples R China
基金
中国国家自然科学基金;
关键词
Gallbladder carcinoma (GBC); Multi-omics; Expression landscape; RNA interaction; COMPREHENSIVE DATABASE; GENE; CANCER;
D O I
10.1186/s12859-023-05133-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to the understanding of the molecular mechanisms of cancer, cancer diagnosis and prognosis. Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb (http://tmliang.cn/gbc/), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. These resources will provide an opportunity for unraveling the potential molecular features of Gallbladder carcinoma.
引用
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页数:10
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