Immunomodulatory properties of mesenchymal stem cells: A potential therapeutic strategy for allergic rhinitis

被引：20

作者：

Wang, Ming ^{[1
,2
]}

Zhao, Ning ^{[3
]}

Wang, Chengshuo ^{[1
,2
]}

Jin, Zi-Bing ^{[3
,5
]}

Zhang, Luo ^{[1
,2
,4
,5
]}

机构：

[1] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China

[2] Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing Lab Allerg Dis, Beijing 100005, Peoples R China

[3] Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China

[4] Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing 100730, Peoples R China

[5] Capital Med Univ, Beijing TongRen Hosp, 1 DongJiaoMinXiang, Beijing, Peoples R China

来源：

ALLERGY | 2023年 / 78卷 / 06期

基金：

北京市自然科学基金; 国家重点研发计划; 中国国家自然科学基金;

关键词：

allergic rhinitis; extracellular vesicles; immunomodulation; mesenchymal stem cells; EOSINOPHILIC CHRONIC RHINOSINUSITIS; QUALITY-OF-LIFE; BONE-MARROW; ADIPOSE-TISSUE; T-CELLS; EXTRACELLULAR VESICLES; AIRWAY INFLAMMATION; CONDITIONED MEDIUM; IMMUNE-RESPONSE; CLINICAL-TRIAL;

D O I：

10.1111/all.15729

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic rhinitis is a highly prevalent chronic inflammatory disorder of the nasal mucosa that poses a significant burden on patients' health and quality of life. Current therapies for allergic rhinitis are unable to reinstate immune homeostasis or are restricted by specific allergens. Potential therapeutic strategies for allergic rhinitis are urgently needed. Mesenchymal stem cells (MSCs) are immune-privileged, have strong immunomodulatory effects, and can be easily isolated from various sources. Thus, MSC-based therapies demonstrate potential for treating inflammatory diseases. Recently, numerous studies have investigated the therapeutic effects of MSCs in animal models of allergic rhinitis. Here, we review the immunomodulatory effects and mechanisms of MSCs on allergic airway inflammation, especially allergic rhinitis, highlight the recent research regarding MSCs in the modulation of immune cells, and discuss the clinical potential of MSC-based therapy for allergic rhinitis.

引用

页码：1425 / 1440

页数：16

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