Impacts of Environmental Pollution on Brain Tumorigenesis

被引：11

作者：

Pagano, Cristina ^{[1
]}

Navarra, Giovanna ^{[1
]}

Coppola, Laura ^{[1
]}

Savarese, Beatrice ^{[1
]}

Avilia, Giorgio ^{[1
]}

Giarra, Antonella ^{[2
]}

Pagano, Giovanni ^{[2
]}

Marano, Alessandra ^{[2
]}

Trifuoggi, Marco ^{[2
]}

Bifulco, Maurizio ^{[1
]}

Laezza, Chiara ^{[3
]}

机构：

[1] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy

[3] Natl Res Council CNR, Inst Endocrinol & Expt Oncol IEOS, I-80131 Naples, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期

关键词：

brain tumor; environmental risk factor; environmental pollutants; heavy metals; toxics; AMBIENT AIR-POLLUTION; LONG-TERM EXPOSURE; PESTICIDE APPLICATORS; OCCUPATIONAL-EXPOSURE; IONIZING-RADIATION; PARTICULATE MATTER; CANCER INCIDENCE; UNITED-STATES; HEAVY-METALS; WATER SOURCE;

D O I：

10.3390/ijms24055045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.

引用

页数：17

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