Omentin-1 Levels and Outcomes in Incident Peritoneal Dialysis Patients

Rationale & Objective: Omentin-1 is an adipokine with anti-inflammatory and cardioprotective properties. The objective of this study was to determine the prognostic role of plasma omentin-1 levels in incident peritoneal dialysis (PD) patients.Study Design: Retrospective analysis of prospec-tive cohort.Setting & Participants: 152 incident PD patients.Predictors: Plasma omentin-1 level, adipose tissue omentin-1 messenger RNA (mRNA) expression. Outcomes: Patient survival, technique survival, hospital admission, and duration of stay.Analytical Approach: Time-to-event survival ana-lyses; linear regression for hospitalization.Results: The mean age was 58.4 +/- 11.7 years; 102 were men, and 92 had diabetes. There was no significant correlation between plasma omentin-1 level and its adipose tissue mRNA expression. A higher plasma omentin-1 level quartile was not associated with patient survival (P = 0.92) or technique survival (P = 0.83) but had a modest correlation with a lower number of hospital admissions (P = 0.07) and shorter duration of hospital stay (P = 0.04). In adjusted models using multivariable linear regression, a higher plasma omentin-1 level quartile remained significantly associated with fewer hospital admissions (6, -0.13; 95% CI,-0.26 to-0.002; P = 0.05) and shorter hospitalization duration (6, -0.20; 95% CI,-0.38 to-0.02; P = 0.03).Limitations: Observational study with baseline measures only.Conclusions: Plasma omentin-1 level was not associated with patient survival, technique survival, or peritonitis, but higher plasma omentin-1 levels were associated with fewer hospital admissions and shorter duration of hospitalization among incident PD patients.