Effect of pharmacogenomic testing on pediatric mental health outcome: a 6-month follow-up

被引：1
|
作者：
Elmaadawi, Ahmed Z. [1 ]
Patel, Rikin [2 ]
Almaaitah, Yarob [3 ]
Logsdon, Matthew G. [4 ]
机构：
[1] Indiana Univ Sch Med, Dept Psychiat, Beacon Hlth Syst, South Bend Campus,707 N Michigan St,Suite 400, South Bend, IN 46601 USA
[2] Duke Univ, Dept Child & Adolescent Psychiat, Med Ctr, Durham, NC 27708 USA
[3] Beacon Med Grp Behav Hlth, Dept Psychiat, 707 N Michigan St, South Bend, IN 46601 USA
[4] Univ Miami, Internal Med Program, Miller Sch Med, 1600 NW 10th Ave 1140, Miami, FL 33136 USA
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 02期
关键词：
ADHD; anxiety; COMT; CYP450; depression; genomically assisted prescribing; methodology; Pediatric; pharmacogenomic testing; ANXIETY DISORDERS; INTERINDIVIDUAL VARIABILITY; CONSENSUS GUIDELINES; ADOLESCENTS; DEPRESSION; CYTOCHROME-P450; CHILDREN; IMPACT; PSYCHIATRY; EFFICACY;
D O I：
10.2217/pgs-2022-0131
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: This retrospective, case-control study evaluated the effect of pharmacogenomic testing (PGT) on the management of pediatrics with anxiety, major depressive disorder (MDD) and attention-deficit/hyperactivity disorder (ADHD). Methods: The authors examined psychiatric diagnoses, medication histories, CYP450 profiles, SLC6A4, HTR2A, COMT and MTHFR. Results: The authors found no difference in clinical improvement between the two groups. However, the number of medication changes was significantly larger after PGT. The treatment response in MDD and anxiety was not different between the groups, while ADHD treatment response was substantially improved in PGT and correlated with COMT status. Conclusion: PGT had some value with ADHD with doubtful benefit for MDD or anxiety disorders. Accordingly, pediatric indications must be weighed against cost, utility and clinician experience. Limitations included sample size and selection bias.
引用
收藏
页码：73 / 82
页数：10
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