Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome

被引：3
作者：
Christersson, Christina [1 ]
Baron, Tomasz [1 ]
Flachskampf, Frank [1 ]
Lindhagen, Lars [2 ]
Lindahl, Bertil [1 ,2 ]
Siegbahn, Agneta [3 ]
机构：
[1] Uppsala Univ, Dept Med Sci, Cardiol, SE-75185 Uppsala, Sweden
[2] Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden
[3] Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2023年 / 16卷 / 01期
关键词：
Soluble biomarkers; Left ventricular function; Acute coronary syndrome; Heart failure; GLOBAL LONGITUDINAL STRAIN; PLASMINOGEN-ACTIVATOR RECEPTOR; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; PROGNOSTIC VALUE; EJECTION FRACTION; IRON-DEFICIENCY; OSTEOPONTIN; REPERFUSION; ECHOCARDIOGRAPHY;
D O I：
10.1007/s12265-022-10285-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A proportion of patients with the acute coronary syndrome (ACS) will suffer progressive remodeling of the left ventricular (LV). The aim was to screen for important biomarkers from a large-scale protein profiling in 420 ACS patients and define biomarkers associated with reduced LV function early and 1 year after the ACS. Transferrin receptor protein 1 and NT-proBNP were associated with LV function early and after 1 year, whereas osteopontin and soluble ST2 were associated with LV function in the early phase and, tissue-type plasminogen activator after 1 year. Fatty-acid-binding protein and galectin 3 were related to worse GLS but not to LVEF 1 year after the ACS. Proteins involved in remodeling and iron transport in cardiomyocytes were related to worse LV function after ACS. Biomarkers for energy metabolism and fibrosis were exclusively related to worse LV function by GLS. Studies on the functions of these proteins might add knowledge to the biological processes involved in heart failure in long term after ACS.
引用
收藏
页码：244 / 254
页数：11
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