B(C6F5)3-Catalyzed Dehydrogenation of Pyrrolidines to Form Pyrroles

被引：6

作者：

Alvarez-Montoya, Ana ^{[1
]}

Gillions, Joseph P. ^{[1
]}

Winfrey, Laura ^{[1
]}

Hawker, Rebecca R. ^{[1
]}

Singh, Kuldip ^{[1
]}

Ortu, Fabrizio ^{[1
]}

Fu, Yukang ^{[2
]}

Li, Yang ^{[2
]}

Pulis, Alexander P. ^{[1
]}

机构：

[1] Univ Leicester, Sch Chem, Leicester LE1 7RH, England

[2] Dalian Univ Technol, Sch Chem Engn, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

ACS CATALYSIS | 2024年 / 14卷 / 07期

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金;

关键词：

dehydrogenation; pyrrolidines; pyrroles; N-heterocycles; catalysis; boranes; METAL-FREE HYDROGENATION; N-HETEROCYCLES; ACID; OXIDATION; AMINES; POLYMERIZATION; AROMATIZATION; REACTIVITY; CLEAVAGE;

D O I：

10.1021/acscatal.3c05444

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Pyrroles are important N-heterocycles found in medicines and materials. The formation of pyrroles from widely accessible pyrrolidines is a potentially attractive strategy but is an underdeveloped approach due to the sensitivity of pyrroles to the oxidative conditions required to achieve such a transformation. Herein, we report a catalytic approach that employs commercially available B(C6F5)(3) in an operationally simple procedure that allows pyrrolidines to serve as direct synthons for pyrroles. Mechanistic studies have revealed insights into borane-catalyzed dehydrogenative processes.

引用

页码：4856 / 4864

页数：9

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