Sympathetic Skin Response in Ulnar Neuropathy at the Elbow

Introduction:The sympathetic skin response (SSR) reflects the function of sudomotor sympathetic unmyelinated fibers. This study evaluates SSR abnormalities in ulnar neuropathy at the elbow (UNE).Methods:Sympathetic skin response was obtained after electrical stimulation of the glabella recording simultaneously from the hand palm (P), third digit (M3) and fifth digit ipsilateral (U5) and contralateral (cU5) to the side of UNE. Ten consecutive SSRs were recorded from each recording side of all participants.Results:The authors enrolled 31 patients (mean age 54.3 +/- 11.4 years) and 25 subjects of a control group (mean age 52.6 +/- 11.3 years). The mean of the areas and the area of the largest response of U5-SSR were significantly lower in the patients (106.9 +/- 68.9 and 127.8 +/- 79.7 mu V/s, respectively) than in control group (161.8 +/- 116.6 and 197.2 +/- 143.3 mu V/s, respectively) and in the affected than in the unaffected sides of the patients (155.3 +/- 84.8 and 197.7 +/- 103.3 mu V/s, respectively); there were no differences in U5-SSR latencies and P-SSR and M3-SSR parameters. U5-SSR mean areas and U5-SSR largest area were reduced in 29% and 26% of patients, respectively. The differences between patients and control group and the number of patients with U5-SSR abnormalities increased when the ratios of M3/U5-SSR and U5/cU5-SSR areas were considered. U5-SSR area was related to UNE clinical severity and to some parameters of the ulnar nerve conduction velocity and cutaneous silent period.Conclusions:Sympathetic skin response is useful to demonstrate abnormalities of sympathetic fibers even if UNE patients do not complain for sympathetic symptoms. The SSR abnormalities were evident only if electrophysiological damage of myelinated fibers was moderate or severe.