Viscoelastic coagulation monitoring for tranexamic acid: personalised antifibrinolytic dosing?

被引：4
作者：
Tanaka, Kenichi A. [1 ]
Bouvette, Sharon M. [1 ]
Butt, Amir L. [1 ]
机构：
[1] Univ Oklahoma, Dept Anaesthesiol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA
来源：
BRITISH JOURNAL OF ANAESTHESIA | 2024年 / 132卷 / 02期
关键词：
coagulation; fibrinolysis; postpartum haemorrhage; tranexamic acid; viscoelastic testing; TISSUE-PLASMINOGEN-ACTIVATOR; IN-VITRO; T-PA; FIBRINOLYSIS; PREGNANCY;
D O I：
10.1016/j.bja.2023.11.041
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Ex vivo viscoelastic testing can be used to assess the concentration responses to tranexamic acid in blood samples obtained from pregnant women across the three trimesters and in non-pregnant controls. Minor variations in fibrinolysis across pregnancy suggest a target tranexamic acid blood concentration of 12.5 mg L-1 for complete inhibition of fibrinolysis. Although the data support the potential utility of viscoelastic testing using the ClotPro (R) TPA test in maintaining therapeutic tranexamic acid concentrations during postpartum haemorrhage, it might obscure potentially crucial endogenous fibrinolysis inhibitor interactions essential to the microcirculation.
引用
收藏
页码：227 / 229
页数：3
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