Glycolysis and acute lung injury: A review

被引：0

作者：

Yi, Yang ^{[1
,2
,3
]}

Chen, Jun ^{[4
]}

Li, Nan ^{[1
,2
,3
]}

Huang, Yue ^{[1
,2
,3
]}

Peng, Jichao ^{[1
,2
,3
]}

Liu, Xiaoran ^{[1
,2
,3
]}

机构：

[1] Hainan Med Univ, Coll Emergency Trauma, Haikou, Peoples R China

[2] Hainan Med Univ, Key Lab Hainan Trauma & Disaster Rescue, Key Lab Hainan Trauma & Disaster Rescue, Haikou, Peoples R China

[3] Hainan Med Univ, Key Lab Emergency & Trauma, Minist Educ, Haikou, Peoples R China

[4] Danzhou Peoples Hosp, Danzhou, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2023年 / 16卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Acute lung injury; Glycolysis; Hypoxia-inducible factor 1; Endothelium; Macrophages; INFLAMMATION; MACROPHAGES; RESPONSES; SEPSIS; CELLS;

D O I：

10.4103/1995-7645.388388

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.

引用

页码：490 / 497

页数：8

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