Associations of specific dietary unsaturated fatty acids with risk of overweight/obesity: population-based cohort study

被引:2
作者
Chen, Weiming [1 ]
Ao, Yang [2 ]
Lan, Xiaochun [3 ]
Tong, Wenzhou [4 ]
Liu, Xiaohui [2 ]
Zhang, Xia [3 ]
Ye, Qiang [1 ]
Li, Yin [2 ]
Liu, Linfen [3 ]
Ye, Hao [2 ]
Zhuang, Pan [5 ]
Zhang, Yu [5 ]
Zheng, Weifang [6 ]
Jiao, Jingjing [2 ]
机构
[1] Lanxi Red Cross Hosp, Jinhua, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Nutr, Hangzhou, Zhejiang, Peoples R China
[3] Lanxi Peoples Hosp, Jinhua, Zhejiang, Peoples R China
[4] Lanxi Ctr Dis Control & Prevent, Jinhua, Peoples R China
[5] Zhejiang Univ, Fuli Inst Food Sci, Coll Biosyst Engn & Food Sci, Dept Food Sci & Nutr, Hangzhou, Zhejiang, Peoples R China
[6] Lanxi Hosp Tradit Chinese Med, Jinhua, Zhejiang, Peoples R China
来源
FRONTIERS IN NUTRITION | 2023年 / 10卷
关键词
unsaturated fatty acids; obesity; overweight; prospective study; China health and nutrition survey; NUTRITION SURVEY; CHINA HEALTH; INSULIN-RESISTANCE; FISH-OIL; OBESITY; OXIDATION; INCREASE; DISEASE; OLEATE; ADULTS;
D O I
10.3389/fnut.2023.1150709
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
BackgroundThe role of specific unsaturated fatty acids (FAs) in the development of overweight/obesity remains unclear in the general population. Here, we aimed to explore the associations of different types of unsaturated FAs with overweight/obesity risk among the Chinese population. MethodsEight thousand seven hundred forty-two subjects free of overweight/obesity at entry in the China Health and Nutrition Survey (CHNS) were followed up until 2015. Dietary unsaturated FAs were assessed by 3-day 24-h recalls with a weighing method in each wave. Cox regression models were used to obtain the hazard ratios (HRs) and 95% confidence intervals (CIs) for overweight/obesity risk associated with unsaturated FAs. ResultsDuring a median follow-up of 7 years, 2,753 subjects (1,350 males and 1,403 females) developed overweight/obesity. Consuming more monounsaturated FAs (MUFAs) was associated with a lower risk of overweight/obesity (highest vs. lowest quartile: HR 0.80, 95% CI 0.67-0.96; P-trend = 0.010). Similar inverse associations were observed for plant-MUFAs (HRQ4vsQ1 0.83, 95% CI: 0.73-0.94; P-trend = 0.003) and animal-MUFAs (HRQ4vsQ1 0.77, 95% CI: 0.64-0.94; P-trend = 0.004), total dietary oleic acid (OA) (HRQ4vsQ1 0.66, 95% CI: 0.55-0.79; P-trend <0.001), plant-OA (HRQ4vsQ1 0.73, 95% CI: 0.64-0.83; P-trend <0.001) and animal-OA (HRQ4vsQ1 0.68, 95% CI: 0.55-0.84; P-trend <0.001). In addition, the intakes of n-3 polyunsaturated FAs (PUFAs) (HRQ4vsQ1 1.24, 95% CI: 1.09-1.42; P-trend = 0.017) and alpha-linolenic acid (ALA) (HRQ4vsQ1 1.22, 95% CI: 1.07-1.39; P-trend = 0.039) but not marine n-3 PUFAs were positively linked to overweight/obesity risk. Consumption of n-6 PUFAs (HRQ4vsQ1 1.13, 95% CI: 0.99-1.28; P-trend = 0.014) and linoleic acid (LA) (HRQ4vsQ1 1.11, 95% CI: 0.98-1.26; P-trend = 0.020) had marginal and positive relationships with the incidence of overweight/obesity. N-6/n-3 PUFA ratio ranging from 5.7 to 12.6 was related to higher risk of overweight/obesity. ConclusionHigher dietary intake of MUFAs was associated with lower overweight/obesity risk, which was mainly driven by dietary OA from either plant or animal sources. Intakes of ALA, n-6 PUFAs and LA were related to higher risk of overweight/obesity. These results support consuming more MUFAs for maintaining a healthy body weight among the Chinese population.
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页数:10
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