Pelvic Pain, Mental Health and Quality of Life in Adolescents with Endometriosis after Surgery and Dienogest Treatment

被引:8
作者
Khashchenko, Elena P. [1 ]
Uvarova, Elena V. [1 ,2 ]
Chuprynin, Vladimir D. [1 ]
Pustynnikova, Margarita Yu. [3 ]
Fatkhudinov, Timur Kh. [1 ,4 ]
Elchaninov, Andrey V. [1 ,4 ]
Gardanova, Zhanna R. [1 ]
Ivanets, Tatyana Yu. [1 ]
Vysokikh, Mikhail Yu. [1 ,5 ]
Sukhikh, Gennady T. [1 ,2 ]
机构
[1] Minist Healthcare Russian Federat, FSBI Natl Med Res Ctr Obstet Gynecol & Perinatol, 4, Oparina St, Moscow 117997, Russia
[2] Sechenov First Moscow State Med Univ, Dept Obstet Gynecol Perinatol & Reprod, Trubetskaya Str 8,Bld 2, Moscow 119991, Russia
[3] Mscow State Univ, Fac Fundamental Med, Moscow 119991, Russia
[4] Peoples Friendship Univ Russia RUDN, Dept Histol Cytol & Embryol, Miklukho Maklaya Str 6, Moscow 117997, Russia
[5] MSU, AN Belozersky Res Inst Phys Chem Biol, Leninskye Gory,House 1,Bldg 40, Moscow 119992, Russia
关键词
endometriosis; adenomyosis; dysmenorrhea; pelvic pain; psycho-emotional status; quality of life; depression; anxiety; progestins; dienogest; adolescents; treatment; WOMEN; IMPACT; PREVALENCE; CYTOKINES; DYSMENORRHEA; DEPRESSION;
D O I
10.3390/jcm12062400
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Diagnostic and treatment delays have caused significant impacts on the physical and emotional well-being of adolescents with endometriosis, though such research is limited. This study aimed to assess the effects of one-year dienogest therapy on the clinical picture, pain patterns, psycho-emotional status, and quality-of-life indicators in adolescents with endometriosis after surgical treatment. Methods: The study enrolled 32 girls aged 13-17 with peritoneal endometriosis to analyze one-year dynamics of the Visual Analog Scale (VAS), McGill Pain Questionnaire, Beck Depression Scale (BDI), Hospital Anxiety and Depression Scale (HADS), Spielberger State-Trait Anxiety Inventory (STAI) and SF-36 quality-of-life survey scores along with clinical and laboratory indicators before surgery and after one-year dienogest therapy. Results. The therapy provided a significant alleviation of endometriosis-associated clinical symptoms, including dysmenorrhea, pelvic pain, gastrointestinal/dysuria symptoms, decreased everyday activity (<0.001), a decrease in anxiety/depression scores (BDI, HADS, STAI), and quality-of-life improvement (<0.001). These effects were accompanied by beneficial dynamics in hormone and inflammatory markers (prolactin, cortisol, testosterone, estradiol, CA-125, neutrophil/lymphocyte ratio; <0.005) within reference ranges. A low body mass index and high C-reactive protein levels were associated with higher VAS scores; a high estradiol level was a factor for anxiety/depression aggravation (<0.05). Conclusions: Dienogest, after surgical treatment, significantly improved quality of life and reduced pain symptoms while showing good tolerability and compliance, and reasoning with timely hormonal therapy in adolescents with endometriosis.
引用
收藏
页数:16
相关论文
共 44 条
[1]  
ABBAS A K., 2021, Cellular and Molecular Immunology
[2]   Psychosocial impact of endometriosis: From co-morbidity to intervention [J].
Aerts, Leen ;
Grangier, Lorraine ;
Streuli, Isabelle ;
Dallenbach, Patrick ;
Marci, Roberto ;
Wenger, Jean-Marie ;
Pluchino, Nicola .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2018, 50 :2-10
[3]  
Ahangari A, 2014, PAIN PHYSICIAN, V17, pE141
[4]  
Ball Elizabeth, 2020, F1000Res, V9, DOI 10.12688/f1000research.20750.1
[5]   ESHRE guideline: endometriosis [J].
Becker, Christian M. ;
Bokor, Attila ;
Heikinheimo, Oskari ;
Horne, Andrew ;
Jansen, Femke ;
Kiesel, Ludwig ;
King, Kathleen ;
Kvaskoff, Marina ;
Nap, Annemiek ;
Petersen, Katrine ;
Saridogan, Ertan ;
Tomassetti, Carla ;
van Hanegem, Nehalennia ;
Vulliemoz, Nicolas ;
Vermeulen, Nathalie .
HUMAN REPRODUCTION OPEN, 2022, 2022 (02)
[6]   The psychological profile of women presenting to a multidisciplinary clinic for chronic pelvic pain: high levels of psychological dysfunction and implications for practice [J].
Bryant, Christina ;
Cockburn, Rebecca ;
Plante, Anne-Florence ;
Chia, Angela .
JOURNAL OF PAIN RESEARCH, 2016, 9 :1049-1056
[7]   Hormonal Status and Cognitivo-Emotional Profile in Real-Life Patients With Neuropathic Pain: A Case Control Study [J].
Corriger, Alexandrine ;
Duclos, Martine ;
Corcuff, Jean-Benoit ;
Lambert, Celine ;
Marceau, Geoffroy ;
Sapin, Vincent ;
Macian, Nicolas ;
Roux, Delphine ;
Pereira, Bruno ;
Pickering, Gisele .
PAIN PRACTICE, 2019, 19 (07) :703-714
[8]   Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms [J].
Coxon, Lydia ;
Home, Andrew W. ;
Vincent, Katy .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2018, 51 :53-67
[9]   A Meta-Analysis of Cytokines in Major Depression [J].
Dowlati, Yekta ;
Herrmann, Nathan ;
Swardfager, Walter ;
Liu, Helena ;
Sham, Lauren ;
Reim, Elyse K. ;
Lanctot, Krista L. .
BIOLOGICAL PSYCHIATRY, 2010, 67 (05) :446-457
[10]   Use of the Short-Form McGill Pain Questionnaire as a Diagnostic Tool in Women with Chronic Pelvic Pain [J].
Droz, Jennifer ;
Howard, Fred M. .
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2011, 18 (02) :211-217