The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

被引：34

作者：

Budi, Hendrik Setia ^{[1
]}

Younus, Laith A. ^{[2
]}

Lafta, Methaq Hadi ^{[3
]}

Parveen, Sameena ^{[4
]}

Mohammad, Hawraa Jabbar ^{[5
]}

Al-qaim, Zahraa Haleem ^{[6
]}

Jawad, Mohammed Abed ^{[7
]}

Parra, Rosario Mireya Romero ^{[8
]}

Mustafa, Yasser Fakri ^{[9
]}

Alhachami, Firas Rahi ^{[10
]}

Karampoor, Sajad ^{[11
]}

Mirzaei, Rasoul ^{[12
]}

机构：

[1] Univ Airlangga, Fac Dent Med, Dept Oral Biol, Dent Pharmacol, Surabaya, Indonesia

[2] Hayyan Med Univ, Fac Pharm, Dept Clin Lab Sci, Jabir Ibn, Iraq

[3] Iraqi Minist Educ, Baghdad, Iraq

[4] Jazan Univ, Coll Dent, Dept Maxillofacial Surg & Diagnost Sci, Jazan, Saudi Arabia

[5] Al Manara Coll Med Sci, Maysan, Iraq

[6] Al Mustaqbal Univ Coll, Dept Anesthesia Tech, Hilla, Iraq

[7] Al Nisour Univ Coll, Baghdad, Iraq

[8] Univ Continental, Lima, Peru

[9] Univ Mosul, Coll Pharm, Dept Pharmaceut Chem, Mosul, Iraq

[10] Al Ayen Univ, Coll Hlth & Med Technol, Radiol Dept, Thi Qar, Iraq

[11] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran

[12] Pasteur Inst Iran, Biotechnol Res Ctr, Med Biotechnol Dept, Venom & Biotherapeut Mol Lab, Tehran, Iran

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 12卷

关键词：

miR-128; cancer progression; cancer suppression; chemoresistance; immunotherapy; CELL LUNG-CANCER; GROWTH-FACTOR RECEPTOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; TUMOR-SUPPRESSOR MIR-128-3P; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; TRANSCRIPTIONAL REPRESSOR; MEDICAL PROGRESS; PROSTATE-CANCER; SKELETAL-MUSCLE;

D O I：

10.3389/fonc.2022.1067974

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.

引用

页数：19

共 192 条

[41] MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness [J].