Heart transplantation and biomarkers: a review about their usefulness in clinical practice

被引：2
作者：
Martini, L. [1 ]
Mandoli, G. E. [1 ]
Pastore, M. C. [1 ]
Pagliaro, A. [2 ]
Bernazzali, S. [2 ]
Maccherini, M. [2 ]
Henein, M. [3 ]
Cameli, M. [1 ]
机构：
[1] Univ Siena, Dept Med Biotechnol, Siena, Italy
[2] Siena Univ Hosp, Cardiothorac Vasc Dept, Siena, Italy
[3] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷
关键词：
heart transplantation; biomarker; CAV; PGD; RVD; rejection; CARDIAC ALLOGRAFT VASCULOPATHY; ANTIBODY-MEDIATED REJECTION; BRAIN NATRIURETIC PEPTIDE; C-REACTIVE PROTEIN; DONOR-SPECIFIC ANTIBODIES; CORONARY-ARTERY-DISEASE; PERICARDIAL FLUID; PEDIATRIC HEART; TROPONIN-I; NONINVASIVE DETECTION;
D O I：
10.3389/fcvm.2024.1336011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. As a result, numerous biomarkers have been investigated in an effort to identify and prevent certain diseases sooner. We looked at both established biomarkers, such as NT-proBNP, hs-troponins, and pro-inflammatory cytokines, and newer ones, such as extracellular vesicles (EVs), donor specific antibodies (DSA), gene expression profile (GEP), donor-derived cell free DNA (dd-cfDNA), microRNA (miRNA), and soluble suppression of tumorigenicity 2 (sST2). These biomarkers are typically linked to complications from HTX. We also highlight the relationships between each biomarker and one or more problems, as well as their applicability in routine clinical practice.
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页数：11
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