Developing novel antifungals: lessons from G protein-coupled receptors

被引：11

作者：

Velazhahan, Vaithish ^{[1
]}

McCann, Bethany L. ^{[2
]}

Bignell, Elaine ^{[2
]}

Tate, Christopher G. ^{[1
]}

机构：

[1] Med Res Council MRC, Lab Mol Biol, Crick Ave, Cambridge CB2 0QH, England

[2] Univ Exeter, MRC Ctr Med Mycol, Stocker Rd, Exeter EX4 4QD, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2023年 / 44卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

PLASMA-MEMBRANE ATPASE; PH RESPONSE PATHWAY; SACCHAROMYCES-CEREVISIAE; ALPHA-FACTOR; MATING PHEROMONE; IN-VITRO; DRUG; TARGETS; VIRULENCE; AGENTS;

D O I：

10.1016/j.tips.2022.12.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was recently declared by the World Health Organization as a global health emergency, but the discovery of new antifungal drug classes remains excruciatingly slow. This process could be accelerated by focusing on novel targets, such as G protein-coupled receptor (GPCR)-like proteins, that have a high likelihood of being druggable and have well-defined biology and roles in disease. We discuss recent successes in understanding the biology of virulence and in structure determination of yeast GPCRs, and highlight new approaches that might pay significant dividends in the urgent search for novel antifungal drugs.

引用

页码：162 / 174

页数：13

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