Abnormalities of cerebral blood flow and the regional brain function in Parkinson's disease: a systematic review and multimodal neuroimaging meta-analysis

被引：4
作者：
Xie, Hao [1 ,2 ]
Yang, Yang [1 ,2 ]
Sun, Qian [1 ,2 ]
Li, Ze-Yang [1 ,2 ]
Ni, Min-Hua [1 ,2 ]
Chen, Zhu-Hong [1 ,2 ]
Li, Si-Ning [1 ,2 ,3 ]
Dai, Pan [1 ,2 ,3 ]
Cui, Yan-Yan [1 ,2 ,4 ]
Cao, Xin-Yu [1 ,2 ,5 ]
Jiang, Nan [1 ,2 ]
Du, Li-Juan [1 ,2 ]
Yu, Ying [1 ,2 ]
Yan, Lin-Feng [1 ,2 ]
Cui, Guang-Bin [1 ,2 ]
机构：
[1] Air Force Med Univ, Mil Med Univ 4, Dept Radiol, Xian, Shaanxi, Peoples R China
[2] Air Force Med Univ, Mil Med Univ 4, Tangdu Hosp, Funct & Mol Imaging Key Lab Shaanxi Prov, Xian, Shaanxi, Peoples R China
[3] Xian Med Univ, Fac Med Technol, Xian, Shaanxi, Peoples R China
[4] Shaanxi Univ Chinese Med, Fac Med Technol, Xianyang, Shaanxi, Peoples R China
[5] Yanan Univ, Fac Med Technol, Med Sch, Yanan, Shaanxi, Peoples R China
来源：
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词：
functional neuroimaging; Parkinson's disease; functional magnetic resonance imaging; cognition; coordinate-based meta-analysis; MILD COGNITIVE IMPAIRMENT; LOW-FREQUENCY FLUCTUATIONS; SPONTANEOUS NEURAL ACTIVITY; RESTING-STATE FMRI; BASAL GANGLIA; DOPAMINERGIC SYSTEM; NEUROVASCULAR UNIT; PERFUSION PATTERN; MOTOR SYMPTOMS; CONNECTIVITY;
D O I：
10.3389/fneur.2023.1289934
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Parkinson's disease (PD) is a neurodegenerative disease with high incidence rate. Resting state functional magnetic resonance imaging (rs-fMRI), as a widely used method for studying neurodegenerative diseases, has not yet been combined with two important indicators, amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF), for standardized analysis of PD.Methods: In this study, we used seed-based d-mapping and permutation of subject images (SDM-PSI) software to investigate the changes in ALFF and CBF of PD patients. After obtaining the regions of PD with changes in ALFF or CBF, we conducted a multimodal analysis to identify brain regions where ALFF and CBF changed together or could not synchronize.Results: The final study included 31 eligible trials with 37 data sets. The main analysis results showed that the ALFF of the left striatum and left anterior thalamic projection decreased in PD patients, while the CBF of the right superior frontal gyrus decreased. However, the results of multimodal analysis suggested that there were no statistically significant brain regions. In addition, the decrease of ALFF in the left striatum and the decrease of CBF in the right superior frontal gyrus was correlated with the decrease in clinical cognitive scores.Conclusion: PD patients had a series of spontaneous brain activity abnormalities, mainly involving brain regions related to the striatum-thalamic-cortex circuit, and related to the clinical manifestations of PD. Among them, the left striatum and right superior frontal gyrus are more closely related to cognition.
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页数：12
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