The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges

被引:21
作者
Mohanty, Sambit K. [1 ,2 ]
Lobo, Anandi [3 ]
Cheng, Liang [4 ,5 ]
机构
[1] Adv Med Res Inst, Dept Pathol & Lab Med, Gurgaon 122016, India
[2] CORE Diagnost, Gurgaon 122016, India
[3] Kapoor Ctr Urol & Pathol, Dept Pathol & Lab Med, Raipur 490042, India
[4] Brown Univ, Warren Alpert Med Sch, Lifespan Acad Med Ctr, Dept Pathol & Lab Med, Providence, RI 02903 USA
[5] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, 593 Eddy St,APC 12-105, Providence, RI 02903 USA
关键词
WHO tumor classifica-tion; Kidney; Renal tumors; Bladder; Testis; Prostate; Penis; Molecular genetics; RENAL-CELL CARCINOMA; INVASIVE BLADDER-CANCER; PROSTATE-CANCER; ARTIFICIAL-INTELLIGENCE; NEUROENDOCRINE TUMORS; FOLLICULAR CARCINOMA; MOLECULAR-PATHOLOGY; LOW-GRADE; DIAGNOSIS; KIDNEY;
D O I
10.1016/j.humpath.2022.08.006
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The fifth edition of the World Health Organization (WHO) classification of urinary and male genital organ tumors has been recently published in 2022. The application of molecular profiling has made a substantial impact on the classification of urologic tumors. The new WHO classification intro-duces a group of molecularly well-defined renal tumor subtypes. The significant changes include addi-tion of a category of "other oncocytic tumors" with oncocytoma/chromophobe renal cell carcinoma (chRCC)-like features, elimination of the subcategorization of type 1/2 papillary RCC, and inclusion of eosinophilic solid and cystic RCC as an independent tumor entity. The WHO/ISUP grading now has been recommended for all RCCs. Major nomenclature changes include replacement of histologic "var-iants" by "subtypes," "clear cell papillary renal cell carcinoma" to "clear cell renal cell tumor," "TCEB1-mutated RCC" to "ELOC-mutated RCC," "hereditary leiomyomatosis and renal cell carci-noma" to "fumarate hydratase-deficient RCC," "RCC-Unclassified" to "RCC-NOS," "primitive neu-roectodermal tumor" to "embryonic neuroectodermal tumor," "testicular carcinoid" to "testicular neuroendocrine tumor," and "basal cell carcinoma of the prostate" to "adenoid-cystic (basal-cell) car-cinoma of the prostate." Metastatic, hematolymphoid, mesenchymal, melanocytic, soft tissue, and neuroendocrine tumors are collectively discussed in separate chapters. It has been suggested that the morphological classification of urothelial cancer be replaced with a new molecular taxonomic classi-fication system. & COPY; 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码:123 / 143
页数:21
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