Copper-catalyzed [3+2] annulation of O-acyl ketoximes with 2-aryl malonates for the synthesis of 3-aryl-4-pyrrolin-2-ones

被引：7

作者：

Song, Xiao-Qing ^{[1
]}

Qiang, Xiao-Qi ^{[1
]}

Hu, Zi-Jun ^{[1
]}

Lyu, Xinyu ^{[1
]}

Tan, Sheng ^{[1
]}

Yao, Changsheng ^{[2
]}

Sun, Yong-Qiang ^{[3
]}

Miao, Chun-Bao ^{[1
]}

Yang, Hai-Tao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Jiangsu Prov Key Lab Fine Petrochem Engn, Changzhou 213164, Peoples R China

[2] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

[3] Changzhou Siyao Pharmaceut Co Ltd, Changzhou 213018, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 35期

关键词：

ALPHA-CONVERTING-ENZYME; C-H ACTIVATION; INTERNAL OXIDANT; OXIME ACETATES; BOND; FUNCTIONALIZATION; CYCLIZATION; INHIBITORS; INDOLES; OLEFINS;

D O I：

10.1039/d3cc00367a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed [3+2] annulation of O-acyl ketoximes with 2-aryl malonates for the concise synthesis of 3-aryl-4-pyrrolin-2-ones has been developed. The advantage of this method lies in the use of O-acyl oximes as an internal oxidant to generate the nucleophilic enamines and electrophilic p-quinone methides concurrently. The subsequent nucleophilic addition undergoes selectively on the a-C of malonates.

引用

页码：5225 / 5228

页数：4

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