Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos

被引：8
作者：
Su, Yufang [1 ]
Fang, Lei [2 ]
Zhong, Kaili [1 ]
Wang, Ting [1 ]
Bao, Mingjie [1 ]
Zhou, Ting [3 ]
Zhu, Yuan [1 ,4 ]
机构：
[1] Nanchang Univ, Jiangxi Prov Maternal & Child Hlth Hosp, Affiliated Maternal & Child Healthcare Hosp, Nanchang, Peoples R China
[2] Jiujiang Univ, Trauma Ctr, Affiliated Hosp, Jiujiang, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Wuhan, Peoples R China
[4] Jiangxi Prov Maternal & Child Hlth Hosp, Dept Gynecol, Nanchang 330006, Jiangxi, Peoples R China
来源：
ENVIRONMENTAL TOXICOLOGY | 2023年 / 38卷 / 03期
基金：
中国国家自然科学基金;
关键词：
immune response; isoliquiritigenin; oxidative stress; transcriptome sequencing; zebrafish embryos; HEPG2; CELLS; EXPRESSION; IMMUNOTOXICITY; TRICLOCARBAN; IMPAIRMENT; RECEPTORS; LICORICE; EXPOSURE; LIVER; OXIDE;
D O I：
10.1002/tox.23715
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Isoliquiritigenin (ISL) is used in many households' personal hygiene and medicinal products, and the average human daily ISL exposure is 1-2 mg/kg. However, the molecular mechanisms of ISL toxicity in zebrafish embryos have not been fully elucidated. We investigated whether exposure to ISL induces oxidative stress and inflammatory responses in zebrafish. And exposure to ISL significantly affects the expression of immune response-related genes in zebrafish embryos following oxidative stress and the release of pro-inflammatory mediators through Toll-like receptor signaling.
引用
收藏
页码：654 / 665
页数：12
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