Curcumin-loaded chitosan-based hydrogels accelerating S. aureus-infected wound healing

被引：9

作者：

Bai, Que ^{[1
]}

Hu, Fangfang ^{[1
]}

Gou, Siyuan ^{[1
]}

Gao, Qian ^{[1
]}

Wang, Shihao ^{[1
]}

Zhang, Wenhui ^{[1
]}

Zhang, Yanni ^{[1
]}

Lu, Tingli ^{[1
,2
]}

机构：

[1] Northwestern Polytech Univ, Engn Res Ctr Chinese, Sch Life Sci,Minist Educ Biol Diag, Key Lab Space Biosci & Biotechnol,Treatment & Prot, Xian 710072, Peoples R China

[2] Shaanxi Liyunzhicai Med Biotechnol Co Ltd, Xixian New Area, Xian 710000, Shaanxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 259卷

关键词：

Chitosan; Hydrogel; Curcumin; ROS reducing; Infected wound healing; MOLECULAR-MECHANISMS; DESIGNING HYDROGELS; BIOACTIVE HYDROGEL; REPAIR;

D O I：

10.1016/j.ijbiomac.2023.129111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its properties and effects on the S. aureus-infected wound healing was tested. It was found the hydrogel showed good antioxidation on the intracellular reactive oxygen species, inhibition on the growth of S. aureus, and acceleration the infected skin healing. The ablity of hydrogel due to its regulating inflammation, promoting angiogenesis and collagen synthesis in the wound site. This research work suggested that the developed multifunctional hydrogel might be a beneficial treatment for the infected wound healing.

引用

页数：13

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