APPLICATION OF INFRARED SPECTROSCOPY AND X-RAY POWDER DIFFRACTOMETRY FOR ASSESSMENT OF THE QUALITATIVE COMPOSITION OF COMPONENTS IN A PHARMACEUTICAL FORMULATION

被引：2

作者：

Stasevych, Maryna ^{[1
]}

Zvarych, Viktor ^{[1
]}

Dronik, Mykhailo ^{[1
]}

Sozanskyi, Martyn ^{[1
]}

Khomyak, Semen ^{[1
]}

机构：

[1] Lviv Polytech Natl Univ, 12 S Bandera St, UA-79013 Lvov, Ukraine

来源：

CHEMISTRY & CHEMICAL TECHNOLOGY | 2023年 / 17卷 / 03期

关键词：

active pharmaceutical ingredient (API); quality composition; API mixture; infrared spectroscopy; X-ray powder diffraction; RELEASE CHARACTERISTICS; DIFFRACTION; 1,4-NAPHTHOQUINONE; DERIVATIVES;

D O I：

10.23939/chcht17.03.510

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A qualitative assessment of a new four -component pharmaceutical composition has been carried out using the methods of infrared spectroscopy and X-ray powder diffractometry. Qualitative characteristics for the identification of mixture components by absorption bands in infrared spectra and characteristic peaks by positions on the scattering angle 2 theta scale in diffractograms were determined. It was experimentally confirmed that the quantitative content of benzocaine and procaine hydrochloride in the mixture without diclofenac sodium decreased by two times compared to their content in the mixture with it. Original infrared spectra and X-ray diffractograms of the new pharmaceutical composition with diclofenac sodium, which can be used for its identification, are presented.

引用

页码：510 / 517

页数：8

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