Local Therapies for Hepatocellular Carcinoma and Role of MRI-Guided Adaptive Radiation Therapy

被引：2

作者：

Liu, Yirong ^{[1
]}

Chou, Brian ^{[2
]}

Yalamanchili, Amulya ^{[1
]}

Lim, Sara N. ^{[1
]}

Dawson, Laura A. ^{[3
]}

Thomas, Tarita O. ^{[1
]}

机构：

[1] Northwestern Med, Dept Radiat Oncol, Chicago, IL 60611 USA

[2] Loyola Univ, Med Ctr, Dept Radiat Oncol, Maywood, IL 60153 USA

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol, Toronto, ON M5S 1A1, Canada

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 10期

关键词：

hepatocellular carcinoma (HCC); liver-directed therapies (LDTs); stereotactic ablative body radiation (SABR); transarterial radioembolization (TARE); MRI-guided SABR; stereotactic MRI-guided on-table adaptive radiotherapy (SMART); STEREOTACTIC BODY RADIOTHERAPY; INDUCED LIVER-DISEASE; VS. RADIOFREQUENCY ABLATION; RANDOMIZED CONTROLLED-TRIAL; TRANSARTERIAL CHEMOEMBOLIZATION; IRREVERSIBLE ELECTROPORATION; Y-90; RADIOEMBOLIZATION; SURGICAL RESECTION; ALBI GRADE; PHASE-III;

D O I：

10.3390/jcm12103517

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatocellular carcinoma (HCC) is the most common liver tumor, with a continually rising incidence. The curative treatment for HCC is surgical resection or liver transplantation; however, only a small portion of patients are eligible due to local tumor burden or underlying liver dysfunction. Most HCC patients receive nonsurgical liver-directed therapies (LDTs), including thermal ablation, transarterial chemoembolization (TACE), transarterial radioembolization (TARE), and external beam radiation therapy (EBRT). Stereotactic ablative body radiation (SABR) is a specific type of EBRT that can precisely deliver a high dose of radiation to ablate tumor cells using a small number of treatments (or fractions, typically 5 or less). With onboard MRI imaging, MRI-guided SABR can improve therapeutic dose while minimizing normal tissue exposure. In the current review, we discuss different LDTs and compare them with EBRT, specifically SABR. The emerging MRI-guided adaptive radiation therapy has been reviewed, highlighting its advantages and potential role in HCC management.

引用

页数：24