New progress in the role of microRNAs in the diagnosis and prognosis of triple negative breast cancer

被引：11

作者：

Fu, Yeqin ^{[1
,2
]}

Yang, Qiuhui ^{[1
,2
]}

Yang, Hongjian ^{[1
]}

Zhang, Xiping ^{[1
]}

机构：

[1] Zhejiang Canc Hosp, Dept Breast Surg, Hangzhou, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2023年 / 10卷

关键词：

triple negative breast cancer; miRNA; diagnosis; prognosis; drug resistance; PROMOTES; GROWTH; CELLS; RNA; PROLIFERATION; SUPPRESSES; ACTIVATION; RESISTANCE; BIOMARKER; PRODRUG;

D O I：

10.3389/fmolb.2023.1162463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triple negative breast cancer is distinguished by its high malignancy, aggressive invasion, rapid progression, easy recurrence, and distant metastases. Additionally, it has a poor prognosis, a high mortality, and is unresponsive to conventional endocrine and targeted therapy, making it a challenging problem for breast cancer treatment and a hotspot for scientific research. Recent research has revealed that certain miRNA can directly or indirectly affect the occurrence, progress and recurrence of TNBC. Their expression levels have a significant impact on TNBC diagnosis, treatment and prognosis. Some miRNAs can serve as biomarkers for TNBC diagnosis and prognosis. This article summarizes the progress of miRNA research in TNBC, discusses their roles in the occurrence, invasion, metastasis, prognosis, and chemotherapy of TNBC, and proposes a treatment strategy for TNBC by interfering with miRNA expression levels.

引用

页数：12

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