Piezo1 in Digestive System Function and Dysfunction

被引：14

作者：

He, Jing ^{[1
]}

Xie, Xiaotian ^{[1
]}

Xiao, Zhuanglong ^{[1
]}

Qian, Wei ^{[1
]}

Zhang, Lei ^{[1
]}

Hou, Xiaohua ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430022, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 16期

关键词：

mechanotransduction; Piezo1; mechanosensitive ion channel; digestive system; biological function; ENTERIC NERVOUS-SYSTEM; ION CHANNELS; MECHANICAL REGULATION; IRON-METABOLISM; STRETCH; CELLS; MECHANORECEPTORS; ARCHITECTURE; MACROPHAGES; MUTATIONS;

D O I：

10.3390/ijms241612953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1's cellular effect across the entire digestive system, and discussed the role of Piezo1 in various aspects including ingestion and digestion, material metabolism, enteric nervous system, intestinal barrier, and inflammatory response within digestive system. The goal of this comprehensive review is to provide a solid foundation for future research about Piezo1 in digestive system physiologically and pathologically.

引用

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