Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata

被引：1

作者：

Chin, Chih-Hui ^{[1
,2
]}

Liaw, Chia-Ching ^{[3
]}

Chang, Tsung-Hsien ^{[4
]}

Shu, Chih-Wen ^{[5
]}

Sung, Ping-Jyun ^{[6
]}

Cheng, Ming-Jen ^{[7
]}

Wang, I-Chou ^{[8
]}

Chen, Jih-Jung ^{[9
,10
]}

机构：

[1] Cathay Gen Hosp, Cardiovasc Ctr, Taipei 106, Taiwan

[2] Fu Jen Catholic Univ, Sch Med, New Taipei City 242, Taiwan

[3] Natl Res Inst Chinese Med, Div Chinese Mat Med Dev, Taipei 112, Taiwan

[4] Natl Def Med Ctr, Inst Microbiol & Immunol, Taipei 114, Taiwan

[5] Natl Sun Yat Sen Univ, Inst BioPharmaceut Sci, Kaohsiung 804, Taiwan

[6] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[7] Fu Jen Catholic Univ, Dept Life Sci, New Taipei City 242, Taiwan

[8] Kaohsiung Vet Gen Hosp Tainan Branch, Dept Phys Med & Rehabil, Tainan 710, Taiwan

[9] Natl Yang Ming Chiao Tung Univ, Sch Pharmaceut Sci, Dept Pharm, Taipei 112, Taiwan

[10] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2024年 / 60卷 / 01期

关键词：

Rhamnus crenata; Rhamnaceae; naphthalene derivative; antioxidant; anti-inflammatory activity;

D O I：

10.1007/s10600-024-04251-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2-9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-alpha-L-rhamnopyranoside (5), and quercetin 7-O-alpha-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 +/- 2.73, 35.52 +/- 3.27, 28.05 +/- 1.85, and 26.41 +/- 3.01 mu M, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 +/- 6.18, 68.27 +/- 5.38, and 66.25 +/- 4.20 mu M, respectively.

引用

页码：50 / 54

页数：5

共 13 条

[1] Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica [J].

Chen, Jih-Jung ;

Yang, Chang-Syun ;

Peng, Chien-Fang ;

Chen, Ih-Sheng ;

Miaw, Chang-Ling .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (06) :1016-1021

[2] Thymol, Benzofuranoid, and Phenylpropanoid Derivatives: Anti-inflammatory Constituents from Eupatorium cannabinum [J].

Chen, Jih-Jung ;

Tsai, Yun-Chen ;

Hwang, Tsong-Long ;

Wang, Tai-Chi .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (05) :1021-1027

[3] Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils [J].

Chen, Jih-Jung ;

Tsai, Cheng-Shuan ;

Hwang, Tsong-Long ;

Shieh, Po-Chuen ;

Chen, Jinn-Fen ;

Sung, Ping-Jyun .

FOOD CHEMISTRY, 2010, 119 (03) :974-980

[4] Biologically active secondary metabolites from the ascomycete A111-95.: 2.: Structure elucidation [J].

Johansson, M ;

Köpcke, B ;

Anke, H ;

Sterner, O .

JOURNAL OF ANTIBIOTICS, 2002, 55 (01) :104-106

[5] Biphenyl-type neolignans from Magnolia officinalis and their anti-inflammatory activities [J].

Kuo, Wen-Lung ;

Chung, Ching-Yi ;

Hwang, Tsong-Long ;

Chen, Jih-Jung .

PHYTOCHEMISTRY, 2013, 85 :153-160

[6] Antioxidant and Anti-a-Glucosidase Activities of Various Solvent Extracts and Major Bioactive Components from the Fruits of Crataegus pinnatifida [J].

Lin, Yen-Ting ;

Lin, Hsiang-Ru ;

Yang, Chang-Syun ;

Liaw, Chia-Ching ;

Sung, Ping-Jyun ;

Kuo, Yueh-Hsiung ;

Cheng, Ming-Jen ;

Chen, Jih-Jung .

ANTIOXIDANTS, 2022, 11 (02)

[7]

Liu T. S., 1993, FLORA TAIWAN, V3, P680

[8]

Mekala AB, 2017, NAT PROD COMMUN, V12, P403

[9]

Mohammed HA., 2015, INT J PHARM PHYTOPHA, V5, P55

[10]

Nigussie G, 2021, Journal of the Turkish Chemical Society Section A Chemistry, V8, P899, DOI [10.18596/jotcsa.929188, 10.18596/jotcsa, DOI 10.18596/JOTCSA, 10.18596/jotcsa.929188, DOI 10.18596/JOTCSA.929188]

← 1 2 →