Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis

被引：0

作者：

Konishi, Risa ^{[1
,2
]}

Ichimura, Yuki ^{[1
,3
]}

Tanaka, Ryota ^{[1
,2
]}

Miyahara, Hanako ^{[2
]}

Okune, Mari ^{[2
]}

Miyamoto, Masahide ^{[4
]}

Hara, Monami ^{[4
]}

Iwabuchi, Atsushi ^{[4
]}

Takada, Hidetoshi ^{[4
]}

Nakagishi, Yasuo ^{[5
]}

Mizuta, Mao ^{[5
]}

Kaneko, Shuya ^{[6
]}

Shimizu, Masaki ^{[6
]}

Morio, Tomohiro ^{[6
]}

Nishino, Ichizo ^{[7
,8
]}

Nomura, Toshifumi ^{[2
]}

Okiyama, Naoko ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Dermatol, Tokyo, Japan

[2] Univ Tsukuba, Fac Med, Dept Dermatol, Ibaraki, Japan

[3] Tokyo Womens Med Univ, Sch Med, Dept Internal Med, Div Rheumatol, Tokyo, Japan

[4] Univ Tsukuba, Fac Med, Dept Pediat, Ibaraki, Japan

[5] Hyogo Prefectural Kobe Childrens Hosp, Dept Pediat Rheumatol, Hyogo, Japan

[6] Tokyo Med & Dent Univ TMDU, Fac Med, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo, Japan

[7] Natl Inst Neurosci, Dept Neuromuscular Res, Bengaluru, India

[8] Natl Ctr Neurol & Psychiat, Med Genome Ctr, Tokyo, Japan

来源：

IMMUNOLOGICAL MEDICINE | 2024年 / 47卷 / 02期

关键词：

Dermatomyositis; nuclear matrix protein 2; interleukin-8; cytokine; POLYMYOSITIS; MUSCLE;

D O I：

10.1080/25785826.2023.2300553

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed quantitative immunoassays using the MILLIPLEX (R) Multiplex Assays Using Luminex to evaluate serum levels of interferon-gamma, interleukin (IL)-1 beta, IL-6, IL-8, IL-12p40, and tumor necrosis factor-alpha in samples collected over time from a 9-year-old female with anti-NXP2 antibody-positive DM. In our case, the serum level of IL-8 was elevated when the myositis worsened, and decreased in accordance with the improvement of myositis, suggesting that the serum IL-8 levels were correlated with the myositis activity. Serum levels of IL-8 in samples from five patients with anti-NXP2 antibody-positive DM and five patients with anti-transcriptional intermediary factor 1 gamma (TIF1 gamma) antibody-positive DM without both interstitial lung disease (ILD) and malignancy before starting treatments, along with five healthy controls, were also evaluate by an enzyme-linked immunosorbent assay. Serum IL-8 levels were significantly elevated in anti-NXP2 or anti-TIF1 gamma antibody-positive DM patients with myositis but not ILD, than healthy controls. It was suggested that serum levels of IL-8 correlate with the activity of myositis in DM including anti-NXP2 antibody-positive DM.

引用

页码：100 / 105

页数：6

共 12 条

[1]

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