Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction

被引:5
作者
Samora, Milena [1 ]
Huo, Yu [1 ]
Mcculler, Richard K. [1 ]
Chidurala, Suchit [1 ]
Stanhope, Kimber L. [2 ,3 ]
Havel, Peter J. [2 ,3 ]
Stone, Audrey J. [1 ]
Harrison, Michelle L. [1 ,4 ]
机构
[1] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX USA
[2] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA USA
[3] Univ Calif Davis, Dept Nutr, Davis, CA USA
[4] Univ Texas Austin, Coll Educ, Dept Kinesiol & Hlth Educ, 2109 San Jacinto Blvd, Austin, TX 78712 USA
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2023年 / 249卷
关键词
UCD-T2DM; Obesity; Insulin; Adiponectin; Baroreflex function; BARORECEPTOR REFLEX CONTROL; SYMPATHETIC-NERVE ACTIVITY; ADIPOSE-SPECIFIC PROTEIN; X-RAY ABSORPTIOMETRY; C-REACTIVE PROTEIN; OBESE ZUCKER RATS; HEART-RATE; INSULIN SENSITIVITY; ARTERIAL-PRESSURE; SPECTRAL-ANALYSIS;
D O I
10.1016/j.autneu.2023.103117
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function, which may be linked to the co-existence of obesity. However, the role of obesity and its related metabolic impairments on baroreflex dysfunction in T2DM is unknown. This study aimed to investigate the role of visceral fat and adiponectin, the most abundant cytokine produced by adipocytes, on baroreflex dysfunction in T2DM rats. Experiments were performed in adult male UCD-T2DM rats assigned to the following experimental groups (n = 6 in each): prediabetic (Pre), diabetes-onset (T0), 4 weeks after onset (T4), and 12 weeks after onset (T12). Age-matched healthy Sprague-Dawley rats were used as controls. Rats were anesthetized and blood pressure was directly measured on a beat-to-beat basis to assess spontaneous baroreflex sensitivity (BRS) using the sequence technique. Dual-energy X-ray absorptiometry (DEXA) was used to assess body composition. Data are presented as mean +/- SD. BRS was significantly lower in T2DM rats compared with controls at T0 (T2D: 3.7 +/- 3.2 ms/mmHg vs Healthy: 16.1 +/- 8.4 ms/mmHg; P = 0.01), but not at T12 (T2D: 13.4 +/- 8.1 ms/mmHg vs Healthy: 9.2 +/- 6.0 ms/ mmHg; P = 0.16). T2DM rats had higher visceral fat mass, adiponectin, and insulin concentrations compared with control rats (all P < 0.01). Changes in adiponectin and insulin concentrations over the measured time-points mirrored one another and were opposite those of the BRS in T2DM rats. These findings demonstrate that obesityrelated metabolic impairments may contribute to an attenuated spontaneous BRS in T2DM, suggesting a link between metabolic and autonomic dysfunction.
引用
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页数:10
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