DNA Sequence-Specific Ligands. 19. Synthesis, Spectral Properties, Virological and Biochemical Studies of DB3(n) Fluorescent Dimeric Trisbenzimidazoles

被引：0

作者：

Arutyunyan, A. F. ^{[1
]}

Kostyukov, A. A. ^{[2
]}

Korolev, S. P. ^{[3
,4
]}

Gottikh, M. B. ^{[3
,4
]}

Kaluzhny, D. N. ^{[1
]}

Susova, O. Yu. ^{[5
]}

Zhuze, A. L. ^{[1
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow 119334, Russia

[3] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[4] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[5] Blokhin Natl Med Res Ctr Oncol, Res Inst Carcinogenesis, Moscow 115478, Russia

来源：

MOLECULAR BIOLOGY | 2023年 / 57卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

DNA; sequence-specific minor-groove ligand; fluorescent dimeric trisbenzimidazoles DB3(n); spectral methods; HIV-1; integrase; DNA topoisomerase I; MINOR-GROOVE; BINDING; BENZIMIDAZOLES; HOECHST-33258; MOLECULES; INHIBITORS; VIRUS;

D O I：

10.1134/S0026893323030020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we synthesized and characterized the properties of a series of new fluorescent DB3(n) narrow-groove ligands. DB3(n) compounds based on dimeric trisbenzimidazoles have the ability to bind to the AT regions of DNA. The synthesis of DB3(n), whose trisbenzimidazole fragments are linked by oligomethylene linkers of different lengths (n = 1, 5, 9), is based on the condensation of the MB3 monomeric trisbenzimidazole with alpha,omega-alkyldicarboxylic acids. DB3(n) proved to be effective inhibitors of the catalytic activity of HIV-1 integrase at submicromolar concentrations (0.20-0.30 mu M). DB3(n) was found to inhibit the catalytic activity of DNA topoisomerase I at low micromolar concentrations.

引用

页码：512 / 521

页数：10

共 13 条

[1] DNA Sequence-Specific Ligands. 19. Synthesis, Spectral Properties, Virological and Biochemical Studies of DB3(n) Fluorescent Dimeric Trisbenzimidazoles
A. F. Arutyunyan
A. A. Kostyukov
S. P. Korolev
M. B. Gottikh
D. N. Kaluzhny
O. Yu. Susova
A. L. Zhuze
Molecular Biology, 2023, 57 : 512 - 521
[2] DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)
Arutyunyan, Albert F. F.
Kostyukov, Alexey A. A.
Lushpa, Vladislav A. A.
Mineev, Konstantin S. S.
Korolev, Sergey P. P.
Gottikh, Marina B. B.
Klimova, Regina R. R.
Kushch, Alla A. A.
Kalabina, Kseniya V. V.
Susova, Olga Yu.
Zhuze, Alexei L. L.
MEDICINAL CHEMISTRY RESEARCH, 2023, 32 (03) : 587 - 599
[3] DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)
Albert F. Arutyunyan
Alexey A. Kostyukov
Vladislav A. Lushpa
Konstantin S. Mineev
Sergey P. Korolev
Marina B. Gottikh
Regina R. Klimova
Alla A. Kushch
Kseniya V. Kalabina
Olga Yu. Susova
Alexei L. Zhuze
Medicinal Chemistry Research, 2023, 32 : 587 - 599
[4] DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n)
Koval, Vasiliy S.
Arutyunyan, Albert F.
Salyanov, Victor L.
Klimova, Regina R.
Kushch, Alla A.
Rybalkina, Ekaterina Yu.
Susova, Olga Yu.
Zhuze, Alexei L.
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (09) : 2302 - 2309
[5] DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n)
Koval, Vasiliy S.
Arutyunyan, Albert F.
Salyanov, Victor, I
Kostyukov, Alexey A.
Melkina, Olga E.
Zavilgelsky, Gennadii B.
Klimova, Regina R.
Kushch, Alla A.
Korolev, Sergey P.
Agapkina, Yulia Yu
Gottikh, Marina B.
Vaiman, Andrey V.
Rybalkina, Ekaterina Yu
Susova, Olga Yu
Zhuze, Alexei L.
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (07)
[6] DNA Sequence-Specific Ligands: XIV. Synthesis of Fluorescent Biologically Active Dimeric Bisbenzimidazoles DB(3,4,5,7,11)
Ivanov, A. A.
Salyanov, V. I.
Strel'tsov, S. A.
Cherepanova, N. A.
Gromova, E. S.
Zhuze, A. L.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2011, 37 (04) : 472 - 482
[7] DNA sequence-specific ligands: XIV. Synthesis of fluorescent biologically active dimeric bisbenzimidazoles DB(3, 4, 5, 7, 11)
A. A. Ivanov
V. I. Salyanov
S. A. Strel’tsov
N. A. Cherepanova
E. S. Gromova
A. L. Zhuze
Russian Journal of Bioorganic Chemistry, 2011, 37 : 472 - 482
[8] DNA sequence-specific ligands: XII. Synthesis and cytological studies of dimeric Hoechst 33258 molecules
Gromyko, AV
Popov, KV
Mosoleva, AP
Streltsov, SA
Grokhovsky, SL
Oleinikov, VA
Zhuze, AL
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2005, 31 (04) : 344 - 351
[9] DNA Sequence-Specific Ligands: XII. Synthesis and Cytological Studies of Dimeric Hoechst 33258 Molecules
A. V. Gromyko
K. V. Popov
A. P. Mosoleva
S. A. Streltsov
S. L. Grokhovsky
V. A. Oleinikov
A. L. Zhuze
Russian Journal of Bioorganic Chemistry, 2005, 31 : 344 - 351
[10] DNA sequence-specific ligands: XV. Synthesis and spectral characteristics of a new series of dimeric bisbenzimidazoles DB(1,2,6,8,9,10,12)
Ivanov, A. A.
Salyanov, V. I.
Zhuze, A. L.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2016, 42 (02) : 183 - 190

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