MST1/2: Important regulators of Hippo pathway in immune system associated diseases

被引：7

作者：

Zhou, Jingjing ^{[1
,2
]}

Li, Lanfang ^{[1
,2
]}

Wu, Baojin ^{[3
]}

Feng, Zhen ^{[1
,2
]}

Lu, Ying ^{[4
]}

Wang, Zuoyun ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Xuhui Cent Hosp, Sch Basic Med Sci, Dept Gastroenterol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Sch Basic Med Sci, Dept Anat & Histoembrvol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Huashan Hosp, Dept Plast Surg, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China

[4] Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Dept Biochem & Mol Biol,Key Lab Metab & Mol Med,Mi, Shanghai 200032, Peoples R China

来源：

CANCER LETTERS | 2024年 / 587卷

基金：

国家重点研发计划;

关键词：

Hippo pathway; MST1; MST2; Immune system; T cells; LEUKOCYTE ADHESION; TUMOR-SUPPRESSOR; T-CELLS; KINASE; LYMPHOCYTE; ACTIVATION; AUTOIMMUNE; RAPL; IMMUNODEFICIENCY; PHOSPHORYLATION;

D O I：

10.1016/j.canlet.2024.216736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hippo signaling pathway is first found in Drosophila and is highly conserved in evolution. Previous studies on this pathway in mammals have revealed its key role in cell proliferation and differentiation, organ size control, and carcinogenesis. Apart from these, recent findings indicate that mammalian Ste20-like kinases 1 and 2 (MST1/2) have significant effects on immune regulation. In this review, we summarize the updated understanding of how MST1/2 affect the regulation of the immune system and the specific mechanism. The effect of MST1/2 on immune cells and its role in the tumor immune microenvironment can alter the body's response to tumor cells. The relationship between MST1/2 and the immune system suggests new directions in the manipulation of immune responses for clinical immunotherapy, especially for tumor treatment.

引用

页数：11

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