O-Alkyl-3,5-di-tert-butyl-4-hydroxybenzylchlorophosphonates in the Synthesis of New Phosphonamidates Containing Sterically Hindered Phenolic and N-Heterocyclic Fragments

被引：0

作者：

Shakirov, A. M. ^{[1
,2
]}

Gibadullina, E. M. ^{[1
]}

Chugunova, E. A. ^{[1
]}

Burilov, A. R. ^{[1
]}

机构：

[1] Russian Acad Sci, AE Arbuzov Inst Organ & Phys Chem, Kazan Sci Ctr, Fed Res Ctr, Kazan 420088, Russia

[2] Kazan Natl Res Technol Univ KNRTU, Kazan 420015, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / SUPPL 2期

基金：

俄罗斯科学基金会;

关键词：

phosphonamidate; sterically hindered phenol; N-heterocycles; drug design; antitumor agents; PRODRUGS; INHIBITOR;

D O I：

10.1134/S1070363223150227

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of eight new phosphonamidates containing sterically hindered phenolic and N-heterocyclic fragments was obtained and characterized. The synthesis is based on the reaction of O-alkyl-3,5-di-tert-butyl-4-hydroxybenzylchlorophosphonates with aliphatic amines.

引用

页码：S577 / S582

页数：6

共 28 条

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