3D convolutional neural network for schizophrenia detection using as EEG-based functional brain network

Schizophrenia (ScZ) is a chronic mental disorder affecting the function of the brain, which causes emotional, social, and cognitive problems. This paper explored the functional brain network and deep learning methods to detect ScZ using electroencephalogram (EEG) signals. Functional brain network analysis was proposed and implemented using a multivariate autoregressive model and coherence connectivity algorithm. The three ma-chine learning techniques and 3D-convolutional neural network (CNN) models were applied to classify the ScZ patients and health control subjects, and then the public LMSU database was utilized to assess the performance. The proposed 3D-CNN method achieved the performance of a 98.47 +/- 1.47 % in accuracy, 99.26 +/- 1.07 % in sensitivity, and 97.23 +/- 3.76 % in specificity. Moreover, in addition to the default mode network region, the temporal and posterior temporal lobes of both right and left hemispheres were found as the significant difference areas in ScZ brain network analysis.