Osteocalcin: A Multifaceted Bone-Derived Hormone

被引:39
作者
Karsenty, Gerard [1 ,2 ]
机构
[1] Columbia Univ, Vagelos Coll Phys & Surg, Dept Genet, New York, NY 10027 USA
[2] Columbia Univ, Vagelos Coll Phys & Surg, Dept Dev, New York, NY 10027 USA
基金
美国国家卫生研究院;
关键词
bone; osteocalcin; undercarboxylation; energy metabolism; danger repellent; K-DEPENDENT PROTEINS; ANOREXIA-NERVOSA; ENDOCRINE; OSTEOPOROSIS; MUSCLE; CELLS;
D O I
10.1146/annurev-nutr-061121-091348
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following its binding to one of three receptors, osteocalcin exerts a profound influence on various aspects of energy metabolism as well as steroidogenesis, neurotransmitter biosynthesis and thereby male fertility, electrolyte homeostasis, cognition, the acute stress response, and exercise capacity. Although this review focuses mostly on the regulation of energy metabolism by osteocalcin, it also touches on its other functions. Lastly, it proposes what could be a common theme between the functions of osteocalcin and between these functions and the structural functions of bone.
引用
收藏
页码:55 / 71
页数:17
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