The FIB-4 Index Predicts the Development of Liver-Related Events, Extrahepatic Cancers, and Coronary Vascular Disease in Patients with NAFLD

被引：15

作者：

Kamada, Yoshihiro ^{[1
]}

Munekage, Kensuke ^{[2
]}

Nakahara, Takashi ^{[3
]}

Fujii, Hideki ^{[4
]}

Sawai, Yoshiyuki ^{[5
]}

Doi, Yoshinori ^{[6
]}

Hyogo, Hideyuki ^{[7
,8
]}

Sumida, Yoshio ^{[9
]}

Imai, Yasuharu ^{[5
]}

Miyoshi, Eiji ^{[10
]}

Ono, Masafumi ^{[11
]}

机构：

[1] Osaka Univ, Dept Adv Metab Hepatol, Grad Sch Med, Suita 5650871, Japan

[2] Kochi Med Sch, Dept Gastroenterol & Hepatol, Nankoku 7838505, Japan

[3] Hiroshima Univ, Dept Gastroenterol & Metab, Hiroshima 7348553, Japan

[4] Osaka Metropolitan Univ, Dept Hepatol, Grad Sch Med, Osaka 5458585, Japan

[5] Ikeda Municipal Hosp, Dept Gastroenterol, Ikeda 5638510, Japan

[6] Otemae Hosp, Dept Gastroenterol, Osaka 5400008, Japan

[7] Hyogo Life Care Clin Hiroshima, 6-34-1 Enkobashi Cho, Minami Ku, Hiroshima 7320823, Japan

[8] JA Hiroshima Gen Hosp, Dept Gastroenterol & Hepatol, Hiroshima 7388503, Japan

[9] Aichi Med Univ, Dept Internal Med, Div Hepatol & Pancreatol, Nagakute 4111195, Japan

[10] Osaka Univ, Dept Mol Biochem & Clin Invest, Grad Sch Med, Suita 5650871, Japan

[11] Kagawa Univ, Fac Med, Div Innovat Med Hepatobiliary & Pancreatol, Takamatsu 7610793, Japan

来源：

NUTRIENTS | 2023年 / 15卷 / 01期

基金：

日本学术振兴会;

关键词：

biopsy-confirmed NAFLD; major adverse cardiovascular events (MACEs); biomarker; noninvasive test (NIT); CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BIOPSY; RISK; ASSOCIATION; MANAGEMENT; FIBROSIS;

D O I：

10.3390/nu15010066

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The prognosis of nonalcoholic fatty liver disease (NAFLD) patients depends on liver-related events (LREs), extrahepatic cancers, and major adverse cardiovascular events (MACEs). The fibrosis-4 (FIB-4) index is one of the most reliable and useful predictors of the degree of liver fibrosis. Recent studies have reported that the FIB-4 index is also useful for predicting LREs and MACEs in NAFLD patients. In the present study, we investigated the prognostic value of the FIB-4 index in NAFLD patients. A total of 506 biopsy-confirmed NAFLD patients from six hepatology centers in Japan from 2002 to 2013 were enrolled in this study. Of these NAFLD patients, 353 were available for more than 100 days of follow-up and did not exhibit events (LREs, extrahepatic cancers, MACEs) at the time of entry. The mean follow-up duration of all the subjects was 2716 +/- 1621 days (102-7483 days). New LREs (hepatocellular carcinoma (HCC) (n = 8), decompensation (n = 11), bleeding varices (n = 8)) developed in 18 patients. Twenty-four and twelve patients developed extrahepatic cancers and MACEs, respectively. The median FIB-4 index was 1.255; we divided our cohort into two groups according to this (FIB4 Low, FIB4 Hi). The incidence of HCC tended to be higher in FIB4 Hi (n = 7) than in FIB4 Low (n = 1). The incidence of LREs was significantly higher in FIB4 Hi (n = 17) than in FIB4 Low (n = 1). The incidence of extrahepatic cancers was significantly higher in FIB4 Hi (n = 20) than in FIB4 Low (n = 4); the incidence of MACEs was also significantly higher in FIB4 Hi (n = 10) than in FIB4 Low (n = 2). The FIB-4 index is a useful biomarker for predicting not only LREs but also extrahepatic cancers and MACEs.

引用

页数：13

共 34 条

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